:Benazepril hydrochloride

Effects and efficacy: Benazepril can be used to treat hypertension and congestive heart failure. It is used as an adjunctive treatment for patients with congestive heart failure (NYHA grade II-IV) who do not respond well to digitalis and/or diuretics.

Usage and dosage: Benazepril is mainly used orally. The specific dosage should be prescribed by the doctor and adjusted by the doctor according to the antihypertensive effect. When patients with hypertension who do not use diuretics start treatment, the recommended daily dose of benazepril is 10 mg, once a day. If the effect is not good, it can be increased to 20 mg per day. The dosage must be adjusted according to the response of blood pressure, usually every 1 to 2 weeks. For some patients, the antihypertensive effect may be weakened at the end of the dosing interval. For such patients, the total daily dose should be divided into two doses, or a diuretic should be added. The maximum recommended daily dose of this product for the treatment of hypertension is 40 mg, taken once or twice. If taking this product alone cannot control blood pressure, a diuretic can be added according to the doctor’s advice. Patients with creatinine clearance ≥30ml/min can take the usual dose. For patients with blood pressure <30ml/min, the initial daily dose is 5mg, and if necessary, the dose can be increased to 10mg/day. If further blood pressure reduction is still required, a diuretic or another antihypertensive drug can be added. Congestive heart failure This product is suitable for adjuvant treatment of patients with congestive heart failure. The recommended initial dose is 2.5mg, once a day. Due to the risk of a sharp drop in blood pressure after the first dose, patients need to be closely monitored when taking this product for the first time. As long as the patient does not experience symptomatic hypotension and other unacceptable adverse reactions, and the symptoms of heart failure are not effectively relieved, the dose can be adjusted to 5mg once a day after 2 to 4 weeks. Depending on the patient's clinical response, the dose can be adjusted to 10mg once a day or even 20mg once a day at appropriate time intervals. This product is effective once a day. For some patients, the response may be better if the daily dose is divided into two doses. Controlled clinical studies have shown that patients with severe heart failure (NYHA grade IV) require a smaller dose than patients with mild and moderate heart failure (NYHA grade II to III). When the creatinine clearance of patients with heart failure is less than 30ml/min, the daily dose can be increased to a maximum of 10mg, but a lower initial dose (such as 2.5mg) may be more ideal. When the creatinine clearance of patients with heart failure is less than 30ml/min, the daily dose can be increased to a maximum of 10mg, but a lower initial dose (2.5mg) may be sufficient. Drug contraindications: Allergic to this product is prohibited. Driving is prohibited during pregnancy. Use with caution Related dosage forms: Tablets, capsules