{"id":10761,"date":"2024-06-30T01:57:12","date_gmt":"2024-06-30T01:57:12","guid":{"rendered":"https:\/\/tycoon-asia.com\/?p=10761"},"modified":"2024-06-30T01:59:17","modified_gmt":"2024-06-30T01:59:17","slug":"23-%d8%a3%d8%af%d9%88%d9%8a%d8%a9-%d8%a7%d9%84%d8%b9%d9%84%d8%a7%d8%ac-%d8%a7%d9%84%d9%83%d9%8a%d9%85%d9%8a%d8%a7%d8%a6%d9%8a-%d8%a7%d9%84%d8%a3%d8%af%d9%88%d9%8a%d8%a9-%d8%a7%d9%84%d9%85%d8%b3","status":"publish","type":"post","link":"https:\/\/tycoon-asia.com\/?p=10761","title":{"rendered":"23 \u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \/ \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0633\u062a\u0647\u062f\u0641\u0629 \/ \u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u0629 \u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645"},"content":{"rendered":"\t\t
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\u064a\u0628\u062f\u0623 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u0641\u064a \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0623\u0648 \u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u0648\u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0633\u0645\u0649 \u0623\u064a\u0636\u064b\u0627 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0623\u0648 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645\u060c \u0627\u0639\u062a\u0645\u0627\u062f\u064b\u0627 \u0639\u0644\u0649 \u0645\u0643\u0627\u0646 \u062d\u062f\u0648\u062b\u0647. \u063a\u0627\u0644\u0628\u064b\u0627 \u0645\u0627 \u064a\u062a\u0645 \u062a\u062c\u0645\u064a\u0639 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u0645\u0639\u064b\u0627 \u0644\u0623\u0646 \u0644\u062f\u064a\u0647\u0645 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0623\u0648\u062c\u0647 \u0627\u0644\u062a\u0634\u0627\u0628\u0647. \u062a\u0628\u062f\u0623 \u0645\u0639\u0638\u0645 \u062d\u0627\u0644\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u0639\u0644\u0649 \u0634\u0643\u0644 \u0633\u0644\u0627\u0626\u0644 \u062a\u0646\u0645\u0648 \u0641\u064a \u0628\u0637\u0627\u0646\u0629 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0623\u0648 \u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645.<\/p>

\u0647\u0646\u0627\u0643 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0641\u0631\u0639\u064a\u0629 \u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645:<\/p>

\u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u063a\u062f\u064a: \u0645\u0639\u0638\u0645 \u0633\u0631\u0637\u0627\u0646\u0627\u062a \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u0647\u064a \u0633\u0631\u0637\u0627\u0646\u0627\u062a \u063a\u062f\u064a\u0629.
\u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629: \u062a\u0646\u0634\u0623 \u0641\u064a \u062e\u0644\u0627\u064a\u0627 \u0645\u062a\u062e\u0635\u0635\u0629 \u0641\u064a \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0641\u064a \u0627\u0644\u0623\u0645\u0639\u0627\u0621. \u0627\u0646\u0638\u0631 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629 \u0641\u064a \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0647\u0636\u0645\u064a.
\u0648\u0631\u0645 \u0627\u0646\u0633\u062c\u0629 \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0647\u0636\u0645\u064a (GIST): \u0623\u0642\u0644 \u0634\u064a\u0648\u0639\u064b\u0627 \u0641\u064a \u0627\u0644\u0642\u0648\u0644\u0648\u0646\u060c \u0627\u0646\u0638\u0631 \u0648\u0631\u0645 \u0627\u0646\u0633\u062c\u0629 \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0647\u0636\u0645\u064a (GIST).
\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u063a\u062f\u062f \u0627\u0644\u0644\u064a\u0645\u0641\u0627\u0648\u064a\u0629 \u0641\u064a \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0647\u0636\u0645\u064a: \u0627\u0646\u0638\u0631 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u063a\u062f\u062f \u0627\u0644\u0644\u064a\u0645\u0641\u0627\u0648\u064a\u0629 \u0627\u0644\u0644\u0627\u0647\u0648\u062f\u062c\u0643\u064a\u0646.
\u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0644\u062d\u0645\u064a\u0629: \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0644\u062d\u0645\u064a\u0629 \u0641\u064a \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0623\u0648 \u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u0646\u0627\u062f\u0631\u0629. \u0623\u0646\u0638\u0631 \u0623\u064a\u0636\u0627: \u0633\u0627\u0631\u0643\u0648\u0645\u0627 \u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u0631\u062e\u0648\u0629.
\u0627\u0644\u062f\u0648\u0627\u0621
\u0641\u064a \u0645\u0639\u0638\u0645 \u0627\u0644\u062d\u0627\u0644\u0627\u062a\u060c \u064a\u0639\u0645\u0644 \u0627\u0644\u062c\u0645\u0639 \u0628\u064a\u0646 \u0627\u062b\u0646\u064a\u0646 \u0623\u0648 \u0623\u0643\u062b\u0631 \u0645\u0646 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062a\u0627\u0644\u064a\u0629 \u0628\u0634\u0643\u0644 \u0623\u0641\u0636\u0644. \u0641\u064a \u0628\u0639\u0636 \u0627\u0644\u0623\u062d\u064a\u0627\u0646 \u064a\u062a\u0645 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0645\u0639 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0633\u062a\u0647\u062f\u0641\u0629. \u064a\u0628\u062f\u0648 \u0623\u0646 \u0643\u0628\u0627\u0631 \u0627\u0644\u0633\u0646 \u064a\u062a\u062d\u0645\u0644\u0648\u0646 \u0623\u0646\u0648\u0627\u0639\u064b\u0627 \u0645\u0639\u064a\u0646\u0629 \u0645\u0646 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u0628\u0634\u0643\u0644 \u062c\u064a\u062f. \u062a\u0634\u0645\u0644 \u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u0629 \u0644\u0639\u0644\u0627\u062c \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u0645\u0627 \u064a\u0644\u064a:<\/p>

1. 5-\u0641\u0644\u0648\u0631\u0648\u064a\u0648\u0631\u0627\u0633\u064a\u0644 (5-FU)
2. \u0643\u0627\u0628\u064a\u0633\u064a\u062a\u0627\u0628\u064a\u0646
3. \u0625\u0631\u064a\u0646\u0648\u062a\u064a\u0643\u0627\u0646
4. \u0623\u0648\u0643\u0633\u0627\u0644\u064a\u0628\u0644\u0627\u062a\u064a\u0646
5. \u062a\u0645\u062a \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 Tigeol [Tegafur (FT)\/Gilmeprazil (CDHP)\/Otylacyl (Oxo)] \u0641\u064a \u0627\u0644\u064a\u0627\u0628\u0627\u0646 \u0641\u064a \u0639\u0627\u0645 2003 \u0644\u0639\u0644\u0627\u062c \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645.
6. \u0644\u0648\u0646\u0633\u0648\u0631\u0641 (\u062a\u0631\u064a\u0641\u0644\u0648\u0631\u064a\u062f\u064a\u0646\/\u062a\u064a\u0628\u064a\u0631\u0627\u0633\u064a\u0644)
7. \u0644\u064a\u0641\u0648\u0641\u0648\u0644\u064a\u0646\u0627\u062a \u062b\u0646\u0627\u0626\u064a \u0627\u0644\u0635\u0648\u062f\u064a\u0648\u0645 (\u0645\u062d\u0644\u0648\u0644 \u062d\u0645\u0636 \u0627\u0644\u0644\u064a\u0641\u0648\u0641\u0648\u0644\u064a\u0646\u064a\u0643 \u0644\u0644\u062d\u0642\u0646\/\u0627\u0644\u062a\u0633\u0631\u064a\u0628)
\u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0633\u062a\u0647\u062f\u0641\u0629 \u0644\u0639\u0644\u0627\u062c \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645<\/p>

\u0628\u064a\u0646\u0645\u0627 \u064a\u062a\u0639\u0644\u0645 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0627\u0644\u0645\u0632\u064a\u062f \u0639\u0646 \u0627\u0644\u062a\u063a\u064a\u0631\u0627\u062a \u0641\u064a \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0648\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0641\u064a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u064a \u062a\u0624\u062f\u064a \u0625\u0644\u0649 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645\u060c \u064a\u062a\u0645 \u062a\u0637\u0648\u064a\u0631 \u0623\u062f\u0648\u064a\u0629 \u062c\u062f\u064a\u062f\u0629 \u0644\u0627\u0633\u062a\u0647\u062f\u0627\u0641 \u0647\u0630\u0647 \u0627\u0644\u062a\u063a\u064a\u064a\u0631\u0627\u062a \u0639\u0644\u0649 \u0648\u062c\u0647 \u0627\u0644\u062a\u062d\u062f\u064a\u062f. \u062a\u0643\u0648\u0646 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0648\u062c\u0647\u0629 \u0641\u0639\u0627\u0644\u0629 \u0639\u0646\u062f\u0645\u0627 \u0644\u0627 \u062a\u0639\u0645\u0644 \u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0627\u0644\u0642\u064a\u0627\u0633\u064a\u0629\u060c \u0648\u063a\u0627\u0644\u0628\u064b\u0627 \u0645\u0627 \u064a\u0643\u0648\u0646 \u0644\u0647\u0627 \u0622\u062b\u0627\u0631 \u062c\u0627\u0646\u0628\u064a\u0629 \u0623\u062e\u0631\u0649 \u0623\u0642\u0644 \u062e\u0637\u0648\u0631\u0629.<\/p>

\u0645\u062b\u0628\u0637\u0627\u062a \u062a\u0643\u0648\u064a\u0646 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629 (VEGF)<\/p>

VEGF (\u0639\u0627\u0645\u0644 \u0646\u0645\u0648 \u0628\u0637\u0627\u0646\u0629 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629) \u0647\u0648 \u0628\u0631\u0648\u062a\u064a\u0646 \u064a\u0633\u0627\u0639\u062f \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0639\u0644\u0649 \u062a\u0643\u0648\u064a\u0646 \u0623\u0648\u0639\u064a\u0629 \u062f\u0645\u0648\u064a\u0629 \u062c\u062f\u064a\u062f\u0629 (\u062a\u0643\u0648\u064a\u0646 \u0627\u0644\u0623\u0648\u0639\u064a\u0629) \u0644\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0627\u0644\u0639\u0646\u0627\u0635\u0631 \u0627\u0644\u063a\u0630\u0627\u0626\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u062d\u062a\u0627\u062c\u0647\u0627 \u0644\u0644\u0646\u0645\u0648. \u062a\u064f\u0633\u062a\u062e\u062f\u0645 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u062a\u062f\u0627\u062e\u0644 \u0645\u0639 VEGF \u0644\u0639\u0644\u0627\u062c \u0628\u0639\u0636 \u0623\u0646\u0648\u0627\u0639 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0623\u0648 \u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645. \u0648\u062a\u0634\u0645\u0644 \u0647\u0630\u0647:<\/p>

8. \u0628\u064a\u0641\u0627\u0633\u064a\u0632\u0648\u0645\u0627\u0628<\/p>

9. \u0631\u0627\u0645\u0648\u0633\u064a\u0631\u0648\u0645\u0627\u0628<\/p>

10. \u0632\u064a\u0641 \u0623\u0641\u0644\u064a\u0628\u0631\u0633\u0628\u062a<\/p>

11. \u0641\u0631\u0648\u0643\u064a\u0646\u062a\u064a\u0646\u064a\u0628<\/p>

Fruquintinib (Aiute) \u0647\u0648 \u0645\u062b\u0628\u0637 \u062c\u0632\u064a\u0621 \u0635\u063a\u064a\u0631 \u064a\u0633\u062a\u0647\u062f\u0641 \u0645\u0633\u062a\u0642\u0628\u0644 \u0639\u0627\u0645\u0644 \u0646\u0645\u0648 \u0628\u0637\u0627\u0646\u0629 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629 (VEGFR). \u062a\u0645 \u062a\u0637\u0648\u064a\u0631\u0647 \u0628\u0648\u0627\u0633\u0637\u0629 \u0634\u0631\u0643\u0629 Hutchison Whampoa \u0648\u062a\u0645\u062a \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u064a\u0647 \u0645\u0646 \u0642\u0628\u0644 \u0627\u0644\u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u0648\u0637\u0646\u064a\u0629 \u0644\u0644\u0645\u0646\u062a\u062c\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0629 \u0641\u064a \u0627\u0644\u0635\u064a\u0646 \u0641\u064a 5 \u0633\u0628\u062a\u0645\u0628\u0631 2018. \u064a\u062a\u0645 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647 \u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645.<\/p>

\u0627\u0644\u0645\u0624\u0634\u0631\u0627\u062a: \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0623\u0648\u0644\u0626\u0643 \u0627\u0644\u0630\u064a\u0646 \u062a\u0644\u0642\u0648\u0627 \u0633\u0627\u0628\u0642\u064b\u0627 \u0639\u0644\u0627\u062c\u064b\u0627 \u0643\u064a\u0645\u064a\u0627\u0626\u064a\u064b\u0627 \u064a\u0639\u062a\u0645\u062f \u0639\u0644\u0649 \u0627\u0644\u0641\u0644\u0648\u0631\u0648\u064a\u0648\u0631\u0627\u0633\u064a\u0644 \u0648\u0627\u0644\u0623\u0648\u0643\u0633\u0627\u0644\u064a\u0628\u0644\u0627\u062a\u064a\u0646 \u0648\u0627\u0644\u0625\u0631\u064a\u0646\u0648\u062a\u064a\u0643\u0627\u0646\u060c \u0623\u0648 \u0627\u0644\u0630\u064a\u0646 \u062a\u0644\u0642\u0648\u0627 \u0633\u0627\u0628\u0642\u064b\u0627 \u0623\u0648 \u063a\u064a\u0631 \u0645\u0624\u0647\u0644\u064a\u0646 \u0644\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0639\u0627\u0645\u0644 \u0646\u0645\u0648 \u0628\u0637\u0627\u0646\u0629 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629 (VEGF) \u0623\u0648 \u0639\u0644\u0627\u062c \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0639\u0627\u0645\u0644 \u0646\u0645\u0648 \u0627\u0644\u0628\u0634\u0631\u0629 (EGFR). \u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u0627\u0644\u0646\u0642\u064a\u0644\u064a (\u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u0628\u0631\u064a ASC).<\/p>

\u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u0648\u0635\u0649 \u0628\u0647\u0627: 5 \u0645\u0644\u063a \u0641\u064a \u0643\u0644 \u0645\u0631\u0629 \u0645\u0631\u0629 \u0648\u0627\u062d\u062f\u0629 \u0641\u064a \u0627\u0644\u064a\u0648\u0645\u061b \u064a\u0624\u062e\u0630 \u0627\u0644\u062f\u0648\u0627\u0621 \u0628\u0634\u0643\u0644 \u0645\u0633\u062a\u0645\u0631 \u0644\u0645\u062f\u0629 3 \u0623\u0633\u0627\u0628\u064a\u0639\u060c \u064a\u0644\u064a\u0647 \u0623\u0633\u0628\u0648\u0639 \u0648\u0627\u062d\u062f \u0645\u0646 \u0627\u0644\u0627\u0646\u0633\u062d\u0627\u0628 (\u0643\u0644 4 \u0623\u0633\u0627\u0628\u064a\u0639 – \u062f\u0648\u0631\u0629 \u0639\u0644\u0627\u062c\u064a\u0629). \u064a\u0645\u0643\u0646 \u062a\u0646\u0627\u0648\u0644 \u0647\u0630\u0627 \u0627\u0644\u0645\u0646\u062a\u062c \u0645\u0639 \u0627\u0644\u0637\u0639\u0627\u0645 \u0623\u0648 \u0628\u062f\u0648\u0646\u0647 \u0648\u064a\u062c\u0628 \u0627\u0628\u062a\u0644\u0627\u0639\u0647 \u0628\u0627\u0644\u0643\u0627\u0645\u0644.
\u0645\u062b\u0628\u0637\u0627\u062a EGFR<\/p>

EGFR (\u0645\u0633\u062a\u0642\u0628\u0644 \u0639\u0627\u0645\u0644 \u0646\u0645\u0648 \u0627\u0644\u0628\u0634\u0631\u0629) \u0647\u0648 \u0628\u0631\u0648\u062a\u064a\u0646 \u064a\u0633\u0627\u0639\u062f \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0646\u0645\u0648. \u062a\u064f\u0633\u062a\u062e\u062f\u0645 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0645\u0646\u0639 EGFR \u0644\u0639\u0644\u0627\u062c \u0628\u0639\u0636 \u062d\u0627\u0644\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0623\u0648 \u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u0627\u0644\u0645\u062a\u0642\u062f\u0645\u0629. \u064a\u0634\u0645\u0644:<\/p>

12. \u0633\u064a\u062a\u0648\u0643\u0633\u064a\u0645\u0627\u0628<\/p>

\u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0631\u062a\u0628\u0637 \u0633\u064a\u062a\u0648\u0643\u0633\u064a\u0645\u0627\u0628 \u0639\u0644\u0649 \u0648\u062c\u0647 \u0627\u0644\u062a\u062d\u062f\u064a\u062f \u0628\u0640 EGFR \u0627\u0644\u0645\u0639\u0628\u0631 \u0639\u0646\u0647 \u0639\u0644\u0649 \u0633\u0637\u062d \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0637\u0628\u064a\u0639\u064a\u0629 \u0648\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629 \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629 \u0648\u064a\u0645\u0646\u0639 \u0628\u0634\u0643\u0644 \u062a\u0646\u0627\u0641\u0633\u064a \u0631\u0628\u0637 EGF \u0648\u0627\u0644\u0631\u0648\u0627\u0628\u0637 \u0627\u0644\u0623\u062e\u0631\u0649 \u0645\u062b\u0644 \u0639\u0627\u0645\u0644 \u0627\u0644\u0646\u0645\u0648 \u0627\u0644\u0645\u062d\u0648\u0644 \u0623\u0644\u0641\u0627 (TGF-\u03b1). \u0648\u0647\u0648 \u062c\u0633\u0645 \u0645\u0636\u0627\u062f \u0623\u062d\u0627\u062f\u064a \u0627\u0644\u0646\u0633\u064a\u0644\u0629 IgG1 \u0645\u0648\u062c\u0647 \u0636\u062f\u0647. \u0645\u0633\u062a\u0642\u0628\u0644 EGF. \u0628\u0639\u062f \u0627\u0644\u062c\u0645\u0639 \u0628\u064a\u0646 \u0647\u0627\u062a\u064a\u0646 \u0627\u0644\u0645\u0627\u062f\u062a\u064a\u0646 \u0639\u0644\u0649 \u0648\u062c\u0647 \u0627\u0644\u062a\u062d\u062f\u064a\u062f\u060c \u0641\u0625\u0646\u0647 \u064a\u0645\u0646\u0639 \u0645\u0633\u0627\u0631 \u0646\u0642\u0644 \u0627\u0644\u0625\u0634\u0627\u0631\u0629 \u062f\u0627\u062e\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0639\u0646 \u0637\u0631\u064a\u0642 \u062a\u062b\u0628\u064a\u0637 \u0627\u0644\u062a\u064a\u0631\u0648\u0632\u064a\u0646 \u0643\u064a\u0646\u0627\u0632 (TK) \u0627\u0644\u0630\u064a \u064a\u0631\u062a\u0628\u0637 \u0628\u0645\u0633\u062a\u0642\u0628\u0644 EGF\u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u062a\u062b\u0628\u064a\u0637 \u062a\u0643\u0627\u062b\u0631 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629\u060c \u0648\u062a\u062d\u0641\u064a\u0632 \u0645\u0648\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0628\u0631\u0645\u062c \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629 \u0648\u062a\u062b\u0628\u064a\u0637 \u0625\u0646\u062a\u0627\u062c \u0645\u0633\u062a\u0642\u0628\u0644 EGF. \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0639\u062f\u0646\u064a\u0629 \u0627\u0644\u0645\u0635\u0641\u0648\u0641\u0629 \u0648\u0639\u0648\u0627\u0645\u0644 \u0646\u0645\u0648 \u0628\u0637\u0627\u0646\u0629 \u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629. \u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u0642\u0628\u0644 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0633\u064a\u062a\u0648\u0643\u0633\u064a\u0645\u0627\u0628\u060c \u064a\u062c\u0628 \u0639\u0644\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u0627\u0644\u0645\u062a\u0643\u0631\u0631 \u0648\u0627\u0644\u0645\u0646\u062a\u0634\u0631 \u0623\u0646 \u064a\u062e\u0636\u0639\u0648\u0627 \u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u062c\u064a\u0646 K-ras \u0644\u0644\u062a\u0623\u0643\u062f \u0645\u0646 \u062d\u0627\u0644\u0629 \u062c\u064a\u0646 K-ras. \u0641\u064a \u062d\u0627\u0644\u0629 \u0648\u062c\u0648\u062f \u0637\u0641\u0631\u0627\u062a \u062c\u064a\u0646 K-ras\u060c \u0641\u0644\u0646 \u064a\u0633\u062a\u0641\u064a\u062f \u0627\u0644\u0645\u0631\u0636\u0649 \u0645\u0646 TKIs \u0627\u0644\u062a\u064a \u062a\u0633\u062a\u0647\u062f\u0641 EGFR.<\/p>


13. \u0628\u0627\u0646\u064a\u062a\u0648\u0645\u0648\u0645\u0627\u0628<\/p>

\u064a\u0639\u062f \u0639\u0642\u0627\u0631 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 (\u0628\u0627\u0646\u064a\u062a\u0648\u0645\u0648\u0645\u0627\u0628) \u0623\u0648\u0644 \u062c\u0633\u0645 \u0645\u0636\u0627\u062f \u0648\u062d\u064a\u062f \u0627\u0644\u0646\u0633\u064a\u0644\u0629 \u0645\u062a\u0648\u0627\u0641\u0642 \u0645\u0639 \u0627\u0644\u0628\u0634\u0631 \u0628\u0627\u0644\u0643\u0627\u0645\u0644 \u0648\u064a\u0633\u062a\u0647\u062f\u0641 \u0645\u0633\u062a\u0642\u0628\u0644 \u0639\u0627\u0645\u0644 \u0646\u0645\u0648 \u0627\u0644\u0628\u0634\u0631\u0629 (EGFR). \u0628\u0627\u0644\u0641\u0639\u0644 \u0641\u064a \u064a\u0648\u0644\u064a\u0648 2005\u060c \u062d\u0635\u0644 \u0627\u0644\u0628\u0627\u0646\u064a\u062a\u0648\u0645\u0648\u0645\u0627\u0628 \u0639\u0644\u0649 \u0645\u0648\u0627\u0641\u0642\u0629 \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 \u0644\u0639\u0644\u0627\u062c \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u0627\u0644\u0646\u0642\u064a\u0644\u064a \u0628\u0639\u062f \u0641\u0634\u0644 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a. \u0623\u062f\u0649 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0628\u0627\u0646\u064a\u062a\u0648\u0645\u0648\u0645\u0627\u0628 \u0645\u0639 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0625\u0644\u0649 \u062a\u062d\u0633\u064a\u0646 \u0645\u0644\u062d\u0648\u0638 \u0641\u064a \u0645\u0639\u062f\u0644 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0645\u0631\u0636 \u0644\u0645\u062f\u0629 9.6 \u0623\u0634\u0647\u0631 \u0648\u0643\u0627\u0646 \u0627\u0644\u062a\u062d\u0645\u0644 \u062c\u064a\u062f\u064b\u0627. \u0628\u0627\u0646\u064a\u062a\u0648\u0645\u0648\u0645\u0627\u0628 \u063a\u064a\u0631 \u0645\u062a\u0648\u0641\u0631 \u062d\u0627\u0644\u064a\u0627 \u0641\u064a \u0627\u0644\u0635\u064a\u0646. \u0641\u064a \u0639\u0627\u0645 2014\u060c \u0623\u0639\u0627\u062f\u062a \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 (\u0628\u0627\u0646\u064a\u062a\u0648\u0645\u0648\u0645\u0627\u0628) \u0628\u0627\u0644\u0627\u0634\u062a\u0631\u0627\u0643 \u0645\u0639 FOLFOX (\u0646\u0638\u0627\u0645 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0627\u0644\u0642\u0627\u0626\u0645 \u0639\u0644\u0649 \u0623\u0648\u0643\u0633\u0627\u0644\u064a\u0628\u0644\u0627\u062a\u064a\u0646) \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062e\u0637 \u0627\u0644\u0623\u0648\u0644 \u0644\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u0627\u0644\u0646\u0642\u064a\u0644\u064a \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u0628\u0631\u064a (\u0625\u0643\u0633\u0648\u0646 2) KRAS.<\/p>

14. \u0631\u064a\u062c\u0648\u0631\u0627\u0641\u064a\u0646\u064a\u0628<\/p>

Regorafenib \u0647\u0648 \u0639\u0644\u0627\u062c \u0645\u0633\u062a\u0647\u062f\u0641 \u0628\u0645\u062b\u0628\u0637\u0627\u062a multikinase. \u0627\u0644\u0643\u064a\u0646\u0627\u0632\u0627\u062a \u0647\u064a \u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0645\u0648\u062c\u0648\u062f\u0629 \u0639\u0644\u0649 \u0633\u0637\u062d \u0627\u0644\u062e\u0644\u064a\u0629 \u0623\u0648 \u0628\u0627\u0644\u0642\u0631\u0628 \u0645\u0646\u0647 \u0648\u062a\u0646\u0642\u0644 \u0625\u0634\u0627\u0631\u0627\u062a \u0645\u0647\u0645\u0629 \u0625\u0644\u0649 \u0645\u0631\u0643\u0632 \u0627\u0644\u062a\u062d\u0643\u0645 \u0641\u064a \u0627\u0644\u062e\u0644\u064a\u0629. \u064a\u0645\u0646\u0639 \u0631\u064a\u062c\u0648\u0631\u0627\u0641\u064a\u0646\u064a\u0628 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0643\u064a\u0646\u0627\u0632\u0627\u062a \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u062a\u064a \u062a\u0633\u0627\u0639\u062f \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0646\u0645\u0648 \u0623\u0648 \u062a\u0633\u0627\u0639\u062f \u0641\u064a \u062a\u0643\u0648\u064a\u0646 \u0623\u0648\u0639\u064a\u0629 \u062f\u0645\u0648\u064a\u0629 \u062c\u062f\u064a\u062f\u0629 \u0644\u062a\u063a\u0630\u064a\u0629 \u0627\u0644\u0623\u0648\u0631\u0627\u0645. \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0633\u0627\u0639\u062f \u062d\u062c\u0628 \u0647\u0630\u0647 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0641\u064a \u0645\u0646\u0639 \u0646\u0645\u0648 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629. \u064a\u0633\u062a\u062e\u062f\u0645 \u0647\u0630\u0627 \u0627\u0644\u062f\u0648\u0627\u0621 \u0644\u0639\u0644\u0627\u062c \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u0627\u0644\u0645\u062a\u0642\u062f\u0645\u060c \u0648\u0639\u0627\u062f\u0629 \u0639\u0646\u062f\u0645\u0627 \u0644\u0627 \u062a\u0643\u0648\u0646 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0623\u062e\u0631\u0649 \u0641\u0639\u0627\u0644\u0629.<\/p>

\u0645\u062b\u0628\u0637 BRAF + \u0645\u062b\u0628\u0637 MEK<\/p>

\u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u0627\u0644\u0645\u062a\u062d\u0648\u0631 \u0628\u0640 BRAF\u060c \u064a\u0645\u0643\u0646 \u0627\u0639\u062a\u0628\u0627\u0631 \u0645\u062b\u0628\u0637 BRAF \u0645\u0639 \u0645\u062b\u0628\u0637 MEK \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0646\u0638\u0627\u0645 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a FOLFOXIRI (5-\u0641\u0644\u0648\u0631\u0648\u064a\u0648\u0631\u0627\u0633\u064a\u0644 + \u0623\u0648\u0643\u0633\u0627\u0644\u064a\u0628\u0644\u0627\u062a\u064a\u0646 + \u0644\u064a\u0648\u0643\u0648\u0641\u0648\u0631\u064a\u0646 + \u0625\u0631\u064a\u0646\u0648\u062a\u064a\u0643\u0627\u0646).<\/p>

15. \u0628\u0631\u0627\u0641\u062a\u0648\u0641\u064a (\u0625\u0646\u0643\u0648\u0631\u0627\u0641\u064a\u0646\u064a\u0628) \u0643\u0627\u0646\u0627\u0641\u064a\u0646\u064a\u0628\u060c \u0648\u0647\u0648 \u0645\u062b\u0628\u0637 BRAF.<\/p>

16. \u0645\u064a\u0643\u062a\u0648\u0641\u064a (\u0628\u064a\u0646\u064a\u0645\u064a\u062a\u064a\u0646\u064a\u0628) \u0645\u062b\u0628\u0637 \u0645\u062c\u0627\u0647\u062f\u064a \u062e\u0644\u0642 (\u0628\u064a\u0645\u064a\u062a\u064a\u0646\u064a\u0628).<\/p>

\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645<\/p>

\u064a\u0645\u0643\u0646 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u062b\u0628\u0637\u0627\u062a \u0646\u0642\u0627\u0637 \u0627\u0644\u062a\u0641\u062a\u064a\u0634 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0644\u062f\u0649 \u0627\u0644\u0623\u0634\u062e\u0627\u0635 \u0627\u0644\u0630\u064a\u0646 \u062a\u0638\u0647\u0631 \u0646\u062a\u0627\u0626\u062c \u0627\u062e\u062a\u0628\u0627\u0631 \u062e\u0644\u0627\u064a\u0627 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u0644\u062f\u064a\u0647\u0645 \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0644\u0644\u062a\u063a\u064a\u0631\u0627\u062a \u0641\u064a \u062c\u064a\u0646\u0627\u062a \u0645\u0639\u064a\u0646\u0629\u060c \u0645\u062b\u0644 \u0627\u0631\u062a\u0641\u0627\u0639 \u0639\u062f\u0645 \u0627\u0633\u062a\u0642\u0631\u0627\u0631 \u0627\u0644\u0623\u0642\u0645\u0627\u0631 \u0627\u0644\u0635\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u062f\u0642\u064a\u0642\u0629 (MSI-H) \u0623\u0648 \u0627\u0644\u062a\u063a\u064a\u0631\u0627\u062a \u0641\u064a \u0623\u062d\u062f \u062c\u064a\u0646\u0627\u062a \u0625\u0635\u0644\u0627\u062d \u0639\u062f\u0645 \u0627\u0644\u062a\u0637\u0627\u0628\u0642 (MMR). \u062a\u064f\u0633\u062a\u062e\u062f\u0645 \u0647\u0630\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0641\u064a \u0627\u0644\u0623\u0634\u062e\u0627\u0635 \u0627\u0644\u0630\u064a\u0646 \u0644\u0627 \u064a\u0632\u0627\u0644 \u0633\u0631\u0637\u0627\u0646\u0647\u0645 \u064a\u0646\u0645\u0648 \u0628\u0639\u062f \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a. \u0648\u064a\u0645\u0643\u0646 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647 \u0623\u064a\u0636\u064b\u0627 \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0623\u0634\u062e\u0627\u0635 \u0627\u0644\u0630\u064a\u0646 \u0644\u0627 \u064a\u0645\u0643\u0646 \u0625\u0632\u0627\u0644\u0629 \u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0644\u062f\u064a\u0647\u0645 \u0628\u0627\u0644\u062c\u0631\u0627\u062d\u0629\u060c \u0623\u0648 \u0639\u0627\u062f \u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0628\u0639\u062f \u0627\u0644\u0639\u0644\u0627\u062c (\u062a\u0643\u0631\u0627\u0631)\u060c \u0623\u0648 \u0627\u0646\u062a\u0634\u0631 \u0625\u0644\u0649 \u0623\u062c\u0632\u0627\u0621 \u0623\u062e\u0631\u0649 \u0645\u0646 \u0627\u0644\u062c\u0633\u0645 (\u0648\u0631\u0645 \u062e\u0628\u064a\u062b).<\/p>

17. \u0628\u064a\u0645\u0628\u0631\u0648\u0644\u064a\u0632\u0648\u0645\u0627\u0628<\/p>

\u0641\u064a 29 \u064a\u0648\u0646\u064a\u0648 2020\u060c \u0623\u0639\u0644\u0646\u062a \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 \u0639\u0646 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 \u0639\u0642\u0627\u0631 \u0643\u064a\u062a\u0631\u0648\u062f\u0627 (\u0628\u064a\u0645\u0628\u0631\u0648\u0644\u064a\u0632\u0648\u0645\u0627\u0628)\u060c \u0627\u0644\u0630\u064a \u0637\u0648\u0631\u062a\u0647 \u0634\u0631\u0643\u0629 \u0645\u064a\u0631\u0643 \u0648\u0634\u0631\u0643\u0627\u0647. (MSD)\u060c \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062e\u0637 \u0627\u0644\u0623\u0648\u0644 \u0645\u0646 \u0639\u062f\u0645 \u0627\u0633\u062a\u0642\u0631\u0627\u0631 \u0627\u0644\u0623\u0642\u0645\u0627\u0631 \u0627\u0644\u0635\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u0635\u063a\u064a\u0631\u0629 \u063a\u064a\u0631 \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u0627\u0643\u062a\u0634\u0627\u0641 \u0623\u0648 \u0627\u0644\u0646\u0642\u064a\u0644\u064a (MSI-H) \u0623\u0648 \u0639\u064a\u0628 \u0639\u062f\u0645 \u0627\u0644\u062a\u0637\u0627\u0628\u0642. (dMMR) \u0641\u064a \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645.<\/p>

18. \u0623\u0648\u0628\u062f\u064a\u0641\u0648 (\u0646\u064a\u0641\u0648\u0644\u0648\u0645\u0627\u0628) \u0623\u0648\u0628\u062f\u064a\u0641\u0648 (\u0646\u064a\u0641\u0648\u0644\u0648\u0645\u0627\u0628)<\/p>

19. \u064a\u0631\u0641\u0648\u064a (\u0625\u064a\u0628\u064a\u0644\u064a\u0645\u0648\u0645\u0627\u0628)<\/p>

\u062a\u0631\u0643\u064a\u0628\u0629 OY: Opdivo+Ervoy \u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u0645\u0632\u064a\u062c \u0641\u0631\u064a\u062f \u0645\u0646 \u0627\u062b\u0646\u064a\u0646 \u0645\u0646 \u0645\u062b\u0628\u0637\u0627\u062a \u0646\u0642\u0627\u0637 \u0627\u0644\u062a\u0641\u062a\u064a\u0634 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0645\u0639 \u0622\u0644\u064a\u0629 \u062a\u0622\u0632\u0631\u064a\u0629 \u0645\u062d\u062a\u0645\u0644\u0629. \u0648\u0647\u0648 \u064a\u0633\u062a\u0647\u062f\u0641 \u0646\u0642\u0637\u062a\u064a \u062a\u0641\u062a\u064a\u0634 \u0645\u062e\u062a\u0644\u0641\u062a\u064a\u0646 (PD-1 \u0648CTLA-4) \u0648\u064a\u0639\u0645\u0644 \u0628\u0637\u0631\u064a\u0642\u0629 \u0645\u062a\u0643\u0627\u0645\u0644\u0629. \u064a\u0633\u0627\u0639\u062f \u0627\u0644\u062c\u0633\u0645 \u0639\u0644\u0649 \u062a\u062f\u0645\u064a\u0631 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629. \u064a\u0633\u0627\u0639\u062f Yervoy (ipilimumab) \u0639\u0644\u0649 \u062a\u0646\u0634\u064a\u0637 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0648\u062a\u0643\u0627\u062b\u0631\u0647\u0627\u060c \u0648\u064a\u0633\u0627\u0639\u062f Opdivo (nivolumab) \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0641\u064a \u0627\u0644\u0639\u062b\u0648\u0631 \u0639\u0644\u0649 \u0627\u0644\u0623\u0648\u0631\u0627\u0645. \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0630\u0644\u0643\u060c \u0641\u0625\u0646 \u0628\u0639\u0636 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0627\u0644\u062a\u064a \u064a\u062d\u0641\u0632\u0647\u0627 \u0627\u0644\u064a\u0631\u0641\u0627 \u062a\u0635\u0628\u062d \u0623\u064a\u0636\u064b\u0627 \u062e\u0644\u0627\u064a\u0627 \u062a\u0627\u0626\u064a\u0629 \u0644\u0644\u0630\u0627\u0643\u0631\u0629\u060c \u0645\u0645\u0627 \u0642\u062f \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0645\u0646\u0627\u0639\u064a\u0629 \u0637\u0648\u064a\u0644\u0629 \u0627\u0644\u0645\u062f\u0649.<\/p>

20. \u0625\u0646\u0641\u064a\u062f\u0627 (\u0625\u0646\u0641\u0648\u0644\u064a\u0645\u0628)<\/p>

\u062a\u0645\u062a \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 Envafolimab \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0628\u0627\u0644\u063a\u064a\u0646 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0623\u0648\u0631\u0627\u0645 \u0635\u0644\u0628\u0629 \u063a\u064a\u0631 \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u0627\u0643\u062a\u0634\u0627\u0641 \u0623\u0648 \u0646\u0642\u064a\u0644\u064a\u0629 \u0639\u0627\u0644\u064a\u0629 \u0639\u062f\u0645 \u0627\u0644\u0627\u0633\u062a\u0642\u0631\u0627\u0631 (MSI-H) \u0623\u0648 \u0623\u0648\u0631\u0627\u0645 \u0635\u0644\u0628\u0629 \u063a\u064a\u0631 \u0645\u062a\u0637\u0627\u0628\u0642\u0629 \u0628\u0633\u0628\u0628 \u0646\u0642\u0635 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0625\u0635\u0644\u0627\u062d\u064a\u0629 (dMMR). \u064a\u0634\u0645\u0644 \u0630\u0644\u0643: \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u0627\u0644\u0645\u062a\u0642\u062f\u0645 \u0648\u0627\u0644\u0630\u064a\u0646 \u062a\u0637\u0648\u0631 \u0645\u0631\u0636\u0647\u0645 \u0628\u0639\u062f \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0633\u0627\u0628\u0642 \u0628\u0627\u0644\u0641\u0644\u0648\u0631\u0648\u064a\u0648\u0631\u0627\u0633\u064a\u0644 \u0648\u0627\u0644\u0623\u0648\u0643\u0633\u0627\u0644\u064a\u0628\u0644\u0627\u062a\u064a\u0646 \u0648\u0627\u0644\u0625\u0631\u064a\u0646\u0648\u062a\u064a\u0643\u0627\u0646\u060c \u0648\u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0623\u0648\u0631\u0627\u0645 \u0635\u0644\u0628\u0629 \u0645\u062a\u0642\u062f\u0645\u0629 \u0623\u062e\u0631\u0649 \u0648\u0627\u0644\u0630\u064a\u0646 \u062a\u0637\u0648\u0631 \u0645\u0631\u0636\u0647\u0645 \u0628\u0639\u062f \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0633\u0627\u0628\u0642 \u0648\u0627\u0644\u0630\u064a\u0646 \u0644\u064a\u0633 \u0644\u062f\u064a\u0647\u0645 \u062e\u064a\u0627\u0631\u0627\u062a \u0639\u0644\u0627\u062c \u0628\u062f\u064a\u0644\u0629 \u0645\u0631\u0636\u064a\u0629.<\/p>

21. SIR-Spheres (\u0643\u0631\u0627\u062a \u0645\u062c\u0647\u0631\u064a\u0629 \u0645\u0646 \u0627\u0644\u0631\u0627\u062a\u0646\u062c \u0627\u0644\u0625\u064a\u062a\u0631\u064a\u0648\u0645 [90Y])<\/p>

\u0627\u0644\u0625\u064a\u062a\u0631\u064a\u0648\u0645-90 \u0627\u0644\u0627\u0646\u0635\u0645\u0627\u0645 \u0627\u0644\u0625\u0634\u0639\u0627\u0639\u064a \u0628\u0627\u0644\u063a\u0644\u0627\u0641 \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u064a (YE) \u0647\u0648 \u062f\u0648\u0627\u0621 \u0646\u0648\u064a\u062f\u0627\u062a \u0645\u0634\u0639\u0629 \u062f\u0627\u062e\u0644\u064a \u0645\u0633\u062a\u0647\u062f\u0641 \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u062e\u0628\u064a\u062b\u0629 \u0641\u064a \u0627\u0644\u0643\u0628\u062f \u0648\u064a\u062c\u0645\u0639 \u0628\u064a\u0646 \u0627\u0644\u0645\u0632\u0627\u064a\u0627 \u0627\u0644\u0645\u0632\u062f\u0648\u062c\u0629 \u0644\u0644\u0645\u0633\u062a\u062d\u0636\u0631\u0627\u062a \u0627\u0644\u0635\u064a\u062f\u0644\u0627\u0646\u064a\u0629 \u0627\u0644\u0625\u0634\u0639\u0627\u0639\u064a\u0629 \u0648\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062a\u062f\u0627\u062e\u0644\u064a \u0627\u0644\u062f\u0642\u064a\u0642.<\/p>

\u0641\u064a \u0639\u0627\u0645 2002\u060c \u062a\u0645\u062a \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0644\u0623\u0648\u0644 \u0645\u0631\u0629 \u0639\u0644\u0649 \u0628\u064a\u0639 \u0643\u0631\u064a\u0627\u062a \u0627\u0644\u0625\u064a\u062a\u0631\u064a\u0648\u0645 [90Y] \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062d\u0642\u0646 \u0641\u064a \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629 \u0648\u0627\u0644\u0627\u062a\u062d\u0627\u062f \u0627\u0644\u0623\u0648\u0631\u0648\u0628\u064a. \u0648\u0628\u0639\u062f \u0645\u0631\u0648\u0631 20 \u0639\u0627\u0645\u064b\u0627\u060c \u0644\u0627 \u064a\u0632\u0627\u0644 \u0627\u0644\u0645\u0646\u062a\u062c \u0627\u0644\u0648\u062d\u064a\u062f \u0641\u064a \u0627\u0644\u0639\u0627\u0644\u0645 \u0644\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0625\u0634\u0639\u0627\u0639\u064a \u0627\u0644\u062f\u0627\u062e\u0644\u064a \u0627\u0644\u0627\u0646\u062a\u0642\u0627\u0626\u064a \u0644\u0644\u0646\u0642\u0627\u0626\u0644 \u0627\u0644\u0643\u0628\u062f\u064a\u0629 \u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645.<\/p>

22. \u062a\u0648\u0643\u064a\u0633\u0627 (\u062a\u0648\u0643\u0627\u062a\u064a\u0646\u064a\u0628)<\/p>

\u0623\u0642\u0631\u0627\u0635 Tucatinib (\u0623\u0642\u0631\u0627\u0635 50 \u0645\u062c\u0645 | 150 \u0645\u062c\u0645) \u0647\u064a \u0623\u062f\u0648\u064a\u0629 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0641\u0645 \u0648\u0647\u064a \u0645\u062b\u0628\u0637\u0627\u062a \u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u062a\u064a\u0631\u0648\u0632\u064a\u0646 \u0643\u064a\u0646\u0627\u0632 HER2. \u0641\u064a \u0627\u0644\u062c\u0633\u0645 \u0627\u0644\u062d\u064a (\u0641\u064a \u0627\u0644\u062c\u0633\u0645 \u0627\u0644\u062d\u064a)\u060c \u064a\u0645\u0646\u0639 TUKYSA \u0646\u0645\u0648 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u062a\u064a \u062a\u0639\u0628\u0631 \u0639\u0646 HER2. \u0623\u0638\u0647\u0631 \u0645\u0632\u064a\u062c TUKYSA \u0648\u0627\u0644\u062c\u0633\u0645 \u0627\u0644\u0645\u0636\u0627\u062f \u0644\u0640 HER2 \u062a\u0631\u0627\u0633\u062a\u0648\u0632\u0648\u0645\u0627\u0628 \u0646\u0634\u0627\u0637\u064b\u0627 \u0645\u0636\u0627\u062f\u064b\u0627 \u0644\u0644\u0623\u0648\u0631\u0627\u0645 \u0641\u064a \u0627\u0644\u0645\u062e\u062a\u0628\u0631 \u0648\u0641\u064a \u0627\u0644\u062c\u0633\u0645 \u0627\u0644\u062d\u064a \u0623\u0643\u0628\u0631 \u0645\u0646 \u0623\u064a \u0645\u0646 \u0627\u0644\u0639\u0642\u0627\u0631\u064a\u0646 \u0648\u062d\u062f\u0647\u0645\u0627.<\/p>

23. Crasati (adagrasib) Adagrasib \u0647\u0648 \u0645\u062b\u0628\u0637 KRAS G12C \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0641\u0645 \u0645\u062d\u062f\u062f \u0644\u0644\u063a\u0627\u064a\u0629 \u0648\u0642\u0648\u064a \u0648\u0645\u064f\u062d\u0633\u0651\u0646 \u0644\u0644\u062a\u062b\u0628\u064a\u0637 \u0627\u0644\u0645\u0633\u062a\u062f\u0627\u0645 \u0648\u0627\u0644\u0645\u0633\u062a\u0647\u062f\u0641. \u064a\u062a\u0645\u062a\u0639 Crasati \u0628\u0646\u0635\u0641 \u0639\u0645\u0631 \u064a\u0635\u0644 \u0625\u0644\u0649 24 \u0633\u0627\u0639\u0629\u060c \u0648\u062a\u0648\u0632\u064a\u0639 \u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0639\u0644\u0649 \u0646\u0637\u0627\u0642 \u0648\u0627\u0633\u0639\u060c \u0648\u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u0639\u0628\u0648\u0631 \u062d\u0627\u062c\u0632 \u0627\u0644\u062f\u0645 \u0641\u064a \u0627\u0644\u062f\u0645\u0627\u063a\u060c \u0645\u0645\u0627 \u064a\u0633\u0627\u0639\u062f \u0639\u0644\u0649 \u0632\u064a\u0627\u062f\u0629 \u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u062f\u0648\u0627\u0621 \u0625\u0644\u0649 \u0623\u0642\u0635\u0649 \u062d\u062f.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

\u064a\u0628\u062f\u0623 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u0641\u064a \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0623\u0648 \u0627\u0644…<\/p>\n","protected":false},"author":1,"featured_media":10762,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-10761","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"jetpack_featured_media_url":"https:\/\/tycoon-asia.com\/wp-content\/uploads\/2024\/06\/3c928ebabc1b9ab2d0a9eae8e53da645.jpg","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=\/wp\/v2\/posts\/10761","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=10761"}],"version-history":[{"count":4,"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=\/wp\/v2\/posts\/10761\/revisions"}],"predecessor-version":[{"id":10766,"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=\/wp\/v2\/posts\/10761\/revisions\/10766"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=\/wp\/v2\/media\/10762"}],"wp:attachment":[{"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=10761"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=10761"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=10761"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}