{"id":10816,"date":"2024-06-30T02:19:29","date_gmt":"2024-06-30T02:19:29","guid":{"rendered":"https:\/\/tycoon-asia.com\/?p=10816"},"modified":"2024-06-30T02:20:15","modified_gmt":"2024-06-30T02:20:15","slug":"opdivo-nivolumab-%d9%85%d8%b9%d8%aa%d9%85%d8%af-%d9%81%d9%8a-%d8%a7%d9%84%d9%88%d9%84%d8%a7%d9%8a%d8%a7%d8%aa-%d8%a7%d9%84%d9%85%d8%aa%d8%ad%d8%af%d8%a9-%d9%84%d9%84%d8%b9%d9%84%d8%a7%d8%ac-%d8%a7","status":"publish","type":"post","link":"https:\/\/tycoon-asia.com\/?p=10816","title":{"rendered":"Opdivo (nivolumab) \u0645\u0639\u062a\u0645\u062f \u0641\u064a \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629 \u0644\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0633\u0627\u0639\u062f \u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0638\u0647\u0627\u0631\u0629 \u0627\u0644\u0628\u0648\u0644\u064a\u0629 (UC)"},"content":{"rendered":"\t\t
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\u064a\u0639\u062a\u0628\u0631 \u0623\u0648\u0628\u062f\u064a\u0641\u0648 (\u0646\u064a\u0641\u0648\u0644\u0648\u0645\u0627\u0628)\u060c \u0627\u0644\u0645\u0639\u0631\u0648\u0641 \u0628\u0627\u0633\u0645 \u0639\u0642\u0627\u0631 O\u060c \u0623\u0648\u0644 \u0645\u062b\u0628\u0637 \u0644\u0640 PD-1 \u0641\u064a \u0627\u0644\u0639\u0627\u0644\u0645. \u0625\u0646\u0647 \u064a\u0633\u062a\u0639\u064a\u062f \u0627\u0644\u0645\u0646\u0627\u0639\u0629 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0648\u0631\u0645 \u0641\u064a \u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u0629 \u0627\u0644\u0628\u0634\u0631\u064a \u0639\u0646 \u0637\u0631\u064a\u0642 \u0645\u0646\u0639 \u0631\u0628\u0637 \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a PD-1 \u0648\u0631\u0648\u0627\u0628\u0637\u0647\u0627. \u0631\u062f \u0641\u0639\u0644. \u062d\u0627\u0644\u064a\u064b\u0627\u060c \u062a\u0645\u062a \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 11 \u0646\u0648\u0639\u064b\u0627 \u0645\u0646 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0641\u064a 66 \u062f\u0648\u0644\u0629 \u0648\u0645\u0646\u0637\u0642\u0629 \u062d\u0648\u0644 \u0627\u0644\u0639\u0627\u0644\u0645\u060c \u062a\u063a\u0637\u064a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0631\u0626\u0629\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0631\u0623\u0633 \u0648\u0627\u0644\u0631\u0642\u0628\u0629\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u0639\u062f\u0629\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u0631\u064a\u0621\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0643\u0628\u062f\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0643\u0644\u0649\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0638\u0647\u0627\u0631\u0629 \u0627\u0644\u0628\u0648\u0644\u064a\u0629\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062c\u0644\u062f\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062c\u0644\u062f. \u0647\u0648\u062f\u062c\u0643\u064a\u0646 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u063a\u062f\u062f \u0627\u0644\u0644\u064a\u0645\u0641\u0627\u0648\u064a\u0629. \u200e\u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u062c\u0646\u0628\u064a\u0629.<\/p>

\u0641\u064a 9 \u0641\u0628\u0631\u0627\u064a\u0631 2021\u060c \u0623\u0639\u0644\u0646\u062a \u0634\u0631\u0643\u0629 \u0628\u0631\u064a\u0633\u062a\u0648\u0644 \u0645\u0627\u064a\u0631\u0632 \u0633\u0643\u0648\u064a\u0628 (BMS) \u0627\u0644\u0635\u064a\u0646\u064a\u0629 \u0639\u0646 \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 CheckMate-274: Opdivo (nivolumab) \u0643\u0639\u0644\u0627\u062c \u0645\u0633\u0627\u0639\u062f \u0644\u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0645\u0633\u0627\u0644\u0643 \u0627\u0644\u0628\u0648\u0644\u064a\u0629 \u0627\u0644\u0639\u0636\u0644\u064a \u0645\u0639 \u0627\u0631\u062a\u0641\u0627\u0639 \u062e\u0637\u0631 \u062a\u0643\u0631\u0627\u0631 \u0627\u0644\u0645\u0631\u0636 \u0644\u0644\u0645\u0631\u0636\u0649 \u0628\u0639\u062f \u0627\u0644\u062c\u0631\u0627\u062d\u0629. \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0644\u0633\u0631\u0637\u0627\u0646\u060c \u062a\u0645 \u0627\u0644\u0648\u0635\u0648\u0644 \u0625\u0644\u0649 \u0646\u0642\u0637\u0629 \u0646\u0647\u0627\u064a\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0623\u0648\u0644\u064a\u0629 \u0641\u064a \u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0633\u0643\u0627\u0646\u064a\u0629 \u0627\u0644\u0639\u0634\u0648\u0627\u0626\u064a\u0629 \u0648\u0641\u064a \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0644\u062f\u064a\u0647\u0645 \u062a\u0639\u0628\u064a\u0631 PD-L1 \u22651%\u060c \u0648\u064a\u0645\u0643\u0646 \u062a\u062d\u0633\u064a\u0646 \u0627\u0644\u0628\u0642\u0627\u0621 \u0639\u0644\u0649 \u0642\u064a\u062f \u0627\u0644\u062d\u064a\u0627\u0629 \u0628\u062f\u0648\u0646 \u0645\u0631\u0636 (DFS) \u0644\u0644\u0645\u0631\u0636\u0649 \u0628\u0634\u0643\u0644 \u0645\u0644\u062d\u0648\u0638.<\/p>

\u0636\u0627\u0639\u0641 \u0646\u064a\u0641\u0648\u0644\u0648\u0645\u0627\u0628 \u062a\u0642\u0631\u064a\u0628\u064b\u0627 \u0628\u0642\u0627\u0621 \u0627\u0644\u0645\u0631\u0636\u0649 \u0639\u0644\u0649 \u0642\u064a\u062f \u0627\u0644\u062d\u064a\u0627\u0629 \u062e\u0627\u0644\u064a\u064b\u0627 \u0645\u0646 \u0627\u0644\u0623\u0645\u0631\u0627\u0636 (DFS) \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0648\u0647\u0645\u064a.
CheckMate -274 \u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u062f\u0631\u0627\u0633\u0629 \u0633\u0631\u064a\u0631\u064a\u0629 \u0639\u0634\u0648\u0627\u0626\u064a\u0629 \u0645\u0632\u062f\u0648\u062c\u0629 \u0627\u0644\u062a\u0639\u0645\u064a\u0629 \u0648\u0645\u062a\u0639\u062f\u062f\u0629 \u0627\u0644\u0645\u0631\u0627\u0643\u0632 \u0645\u0646 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 3 \u0645\u0635\u0645\u0645\u0629 \u0644\u062a\u0642\u064a\u064a\u0645 \u0641\u0639\u0627\u0644\u064a\u0629 \u0648\u0633\u0644\u0627\u0645\u0629 Opdivo \u0645\u0642\u0627\u0631\u0646\u0629 \u0645\u0639 \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0648\u0647\u0645\u064a \u0641\u064a \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0638\u0647\u0627\u0631\u0629 \u0627\u0644\u0628\u0648\u0644\u064a\u0629 \u0627\u0644\u063a\u0627\u0632\u064a\u0629 \u0644\u0644\u0639\u0636\u0644\u0627\u062a \u0648\u0627\u0644\u0630\u064a\u0646 \u064a\u062a\u0639\u0631\u0636\u0648\u0646 \u0644\u062e\u0637\u0631 \u0643\u0628\u064a\u0631 \u0644\u0644\u062a\u0643\u0631\u0627\u0631 \u0628\u0639\u062f \u0627\u0644\u062c\u0631\u0627\u062d\u0629 \u0627\u0644\u062c\u0630\u0631\u064a\u0629. \u0643\u0627\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0645\u0624\u0647\u0644\u064a\u0646 \u0628\u063a\u0636 \u0627\u0644\u0646\u0638\u0631 \u0639\u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646\u0648\u0627 \u0642\u062f \u062a\u0644\u0642\u0648\u0627 \u0639\u0644\u0627\u062c\u064b\u0627 \u0645\u0633\u0627\u0639\u062f\u064b\u0627 \u062c\u062f\u064a\u062f\u064b\u0627 \u0642\u0628\u0644 \u0627\u0644\u062c\u0631\u0627\u062d\u0629\u060c \u0648\u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0648\u0646 \u062a\u0644\u0642\u0648\u0627 \u0639\u0644\u0627\u062c \u0633\u064a\u0633\u0628\u0644\u0627\u062a\u064a\u0646 \u0645\u0633\u0627\u0639\u062f\u064b\u0627 \u062c\u062f\u064a\u062f\u064b\u0627 \u0643\u0627\u0646 \u0639\u0627\u0645\u0644\u0627\u064b \u0637\u0628\u0642\u064a\u064b\u0627 \u0641\u064a \u0627\u0644\u062f\u0631\u0627\u0633\u0629. \u062a\u0645 \u0627\u062e\u062a\u064a\u0627\u0631\u0647\u0645 \u0628\u0635\u0648\u0631\u0629 \u0639\u0634\u0648\u0627\u0626\u064a\u0629 \u0645\u0627 \u0645\u062c\u0645\u0648\u0639\u0647 709 \u0645\u0631\u064a\u0636\u0627 \u0628\u0646\u0633\u0628\u0629 1: 1 \u0644\u062a\u0644\u0642\u064a \u0646\u064a\u0641\u0648\u0644\u0648\u0645\u0627\u0628 240 \u0645\u0644\u063a \u0643\u0644 \u0623\u0633\u0628\u0648\u0639\u064a\u0646 \u0623\u0648 \u062f\u0648\u0627\u0621 \u0648\u0647\u0645\u064a \u0644\u0645\u062f\u0629 \u062a\u0635\u0644 \u0625\u0644\u0649 \u0633\u0646\u0629 \u0648\u0627\u062d\u062f\u0629. \u0646\u0642\u0637\u0629 \u0627\u0644\u0646\u0647\u0627\u064a\u0629 \u0627\u0644\u0623\u0648\u0644\u064a\u0629 \u0644\u0644\u062f\u0631\u0627\u0633\u0629 \u0647\u064a \u0627\u0644\u0628\u0642\u0627\u0621 \u062e\u0627\u0644\u064a\u064b\u0627 \u0645\u0646 \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0644\u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u062a\u0645 \u0627\u062e\u062a\u064a\u0627\u0631\u0647\u0645 \u0628\u0634\u0643\u0644 \u0639\u0634\u0648\u0627\u0626\u064a (\u0623\u064a \u0627\u0644\u0633\u0643\u0627\u0646 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u062a\u0632\u0645\u0648\u0646 \u0627\u0644\u0639\u0644\u0627\u062c) \u0648\u0644\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u062a\u0639\u0628\u0631 \u0623\u0648\u0631\u0627\u0645\u0647\u0645 \u0639\u0646 PD-L1 \u22651%. \u062a\u0634\u0645\u0644 \u0646\u0642\u0627\u0637 \u0627\u0644\u0646\u0647\u0627\u064a\u0629 \u0627\u0644\u062b\u0627\u0646\u0648\u064a\u0629 \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629 \u0627\u0644\u0628\u0642\u0627\u0621 \u0639\u0644\u0649 \u0642\u064a\u062f \u0627\u0644\u062d\u064a\u0627\u0629 \u0628\u0634\u0643\u0644 \u0639\u0627\u0645 (OS)\u060c \u0648\u0627\u0644\u0628\u0642\u0627\u0621 \u0639\u0644\u0649 \u0642\u064a\u062f \u0627\u0644\u062d\u064a\u0627\u0629 \u0628\u062f\u0648\u0646 \u0627\u0646\u062a\u0643\u0627\u0633\u0629 \u063a\u064a\u0631 \u0628\u0648\u0644\u064a\u0629 (NUTRFS)\u060c \u0648\u0627\u0644\u0628\u0642\u0627\u0621 \u0639\u0644\u0649 \u0642\u064a\u062f \u0627\u0644\u062d\u064a\u0627\u0629 \u0644\u0645\u0631\u0636 \u0645\u062d\u062f\u062f (DSS).<\/p>

\u0623\u0638\u0647\u0631\u062a \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0623\u0646\u0647 \u0641\u064a \u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0633\u0643\u0627\u0646\u064a\u0629 \u0627\u0644\u0639\u0634\u0648\u0627\u0626\u064a\u0629\u060c \u062a\u0636\u0627\u0639\u0641 \u062a\u0642\u0631\u064a\u0628\u064b\u0627 \u0645\u062a\u0648\u0633\u0637 \u200b\u200bDFS [21.0 \u0634\u0647\u0631\u064b\u0627] \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062a\u064a \u062a\u0644\u0642\u062a \u0646\u064a\u0641\u0648\u0644\u0648\u0645\u0627\u0628 \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0645\u062a\u0648\u0633\u0637 \u200b\u200bDFS [10.9 \u0634\u0647\u0631\u064b\u0627] \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062a\u062d\u0643\u0645 \u0627\u0644\u0648\u0647\u0645\u064a\u0629\u061b \u062a\u0645 \u062a\u0642\u0644\u064a\u0644 \u0627\u0644\u0645\u062e\u0627\u0637\u0631 \u0628\u0646\u0633\u0628\u0629 30\u066a. \u0641\u064a \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u062a\u0639\u0628\u064a\u0631 PD-L1 \u22651%\u060c \u0642\u0644\u0644 \u0646\u064a\u0641\u0648\u0644\u0648\u0645\u0627\u0628 \u0645\u0646 \u062e\u0637\u0631 \u062a\u0643\u0631\u0627\u0631 \u0627\u0644\u0645\u0631\u0636 \u0623\u0648 \u0627\u0644\u0648\u0641\u0627\u0629 \u0628\u0646\u0633\u0628\u0629 47%\u060c \u0645\u0639 \u0645\u062a\u0648\u0633\u0637 \u200b\u200bDFS \u0644\u0645 \u064a\u062a\u0645 \u0627\u0644\u0648\u0635\u0648\u0644 \u0625\u0644\u064a\u0647 \u064810.8 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u062a\u062d\u0643\u0645 \u0627\u0644\u062e\u0627\u0635\u0629 \u0628\u0627\u0644\u0646\u064a\u0641\u0648\u0644\u0648\u0645\u0627\u0628 \u0648\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0648\u0647\u0645\u064a\u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a. \u0642\u0645\u0631.<\/p>

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\u064a\u0639\u062a\u0628\u0631 \u0623\u0648\u0628\u062f\u064a\u0641\u0648 (\u0646\u064a\u0641\u0648\u0644\u0648\u0645\u0627\u0628)\u060c \u0627\u0644\u0645\u0639\u0631\u0648\u0641 \u0628\u0627\u0633\u0645 \u0639\u0642\u0627\u0631 …<\/p>\n","protected":false},"author":1,"featured_media":10817,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-10816","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"jetpack_featured_media_url":"https:\/\/tycoon-asia.com\/wp-content\/uploads\/2024\/06\/v2-2b3844218380a6fedb451ac42081164f_1440w.webp","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=\/wp\/v2\/posts\/10816","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=10816"}],"version-history":[{"count":4,"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=\/wp\/v2\/posts\/10816\/revisions"}],"predecessor-version":[{"id":10821,"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=\/wp\/v2\/posts\/10816\/revisions\/10821"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=\/wp\/v2\/media\/10817"}],"wp:attachment":[{"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=10816"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=10816"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=10816"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}