{"id":10823,"date":"2024-06-30T02:21:52","date_gmt":"2024-06-30T02:21:52","guid":{"rendered":"https:\/\/tycoon-asia.com\/?p=10823"},"modified":"2024-06-30T02:23:02","modified_gmt":"2024-06-30T02:23:02","slug":"%d8%aa%d9%85-%d8%af%d9%85%d8%ac-padcev-%d9%85%d8%b9-keytruda-%d8%a8%d9%8a%d9%85%d8%a8%d8%b1%d9%88%d9%84%d9%8a%d8%b2%d9%88%d9%85%d8%a7%d8%a8-%d8%a7%d9%84%d9%85%d8%b9%d8%aa%d9%85%d8%af-%d9%81%d9%8a","status":"publish","type":"post","link":"https:\/\/tycoon-asia.com\/?p=10823","title":{"rendered":"\u062a\u0645 \u062f\u0645\u062c Padcev \u0645\u0639 Keytruda (\u0628\u064a\u0645\u0628\u0631\u0648\u0644\u064a\u0632\u0648\u0645\u0627\u0628) \u0627\u0644\u0645\u0639\u062a\u0645\u062f \u0641\u064a \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629 \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062e\u0637 \u0627\u0644\u0623\u0648\u0644 \u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u062b\u0627\u0646\u0629"},"content":{"rendered":"\t\t
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29 \u0645\u0627\u0631\u0633 2023 (\u0644\u0648\u064a\u060c \u0646\u064a\u0648\u062c\u064a\u0631\u0633\u064a) \u0634\u0631\u0643\u0629 Merck & Co.\u060c \u0627\u0644\u0645\u0639\u0631\u0648\u0641\u0629 \u0628\u0627\u0633\u0645 Merck & Co. (MSD) \u062e\u0627\u0631\u062c \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629 \u0648\u0643\u0646\u062f\u0627\u060c \u0627\u0644\u064a\u0648\u0645 \u0623\u0646 \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629. \u0645\u0646\u062d\u062a \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 (FDA) \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u0643\u0627\u0645\u0644\u0629 \u0639\u0644\u0649 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0636\u0627\u062f \u0644\u0640 PD-1 \u0645\u0646 \u0634\u0631\u0643\u0629 Merck\u060c \u0648\u0627\u0644\u0645\u0634\u0627\u0631 \u0625\u0644\u064a\u0647 \u0628\u0627\u0633\u0645 KEYTRUDA \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0628\u0627\u0644\u063a\u064a\u0646 \u0648\u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0627\u0631\u062a\u0641\u0627\u0639 \u0639\u062f\u0645 \u0627\u0633\u062a\u0642\u0631\u0627\u0631 \u0627\u0644\u0623\u0642\u0645\u0627\u0631 \u0627\u0644\u0635\u0646\u0627\u0639\u064a\u0629 \u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u063a\u064a\u0631 \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u0627\u0643\u062a\u0634\u0627\u0641 \u0623\u0648 \u0627\u0644\u0646\u0642\u064a\u0644\u064a (MSI-H) \u0623\u0648 \u0646\u0642\u0635 \u0625\u0635\u0644\u0627\u062d \u0639\u062f\u0645 \u0627\u0644\u062a\u0637\u0627\u0628\u0642 (dMMR) \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0635\u0644\u0628\u0629\u060c \u0648\u0641\u0642\u064b\u0627 \u0644\u0645\u0627 \u064a\u062d\u062f\u062f\u0647 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u0645\u0639\u062a\u0645\u062f \u0645\u0646 \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621. \u0627\u0644\u062a\u0642\u062f\u0645 \u0628\u0639\u062f \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0633\u0627\u0628\u0642 \u0648\u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u062e\u064a\u0627\u0631\u0627\u062a \u0639\u0644\u0627\u062c\u064a\u0629 \u0628\u062f\u064a\u0644\u0629 \u0645\u0631\u0636\u064a\u0629.<\/p>

\u0627\u0633\u062a\u0646\u062f \u0627\u0644\u0627\u0646\u062a\u0642\u0627\u0644 \u0645\u0646 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u0633\u0631\u064a\u0639\u0629 \u0625\u0644\u0649 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u0643\u0627\u0645\u0644\u0629 (\u0627\u0644\u0639\u0627\u062f\u064a\u0629) \u0625\u0644\u0649 \u0646\u062a\u0627\u0626\u062c \u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 KEYNOTE-158 \u0648KEYNOTE-164 \u0648KEYNOTE-051\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0628\u064a\u0627\u0646\u0627\u062a \u0645\u0646 504 \u0645\u0631\u0636\u0649 \u0628\u0627\u0644\u063a\u064a\u0646 \u0648\u0623\u0637\u0641\u0627\u0644 \u0641\u064a \u0623\u0643\u062b\u0631 \u0645\u0646 30 \u062d\u0627\u0644\u0629 \u0633\u0631\u0637\u0627\u0646. \u0648\u0647\u0630\u0647 \u0647\u064a \u0627\u0644\u0645\u0631\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0627\u0644\u062a\u064a \u062a\u062a\u0645 \u0641\u064a\u0647\u0627 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0628\u0634\u0643\u0644 \u0643\u0627\u0645\u0644 \u0639\u0644\u0649 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0627\u0644\u0642\u0627\u0626\u0645 \u0639\u0644\u0649 \u0627\u0644\u0645\u0624\u0634\u0631\u0627\u062a \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0627\u0644\u062a\u0646\u0628\u0624\u064a\u0629.<\/p>

\u0627\u0633\u062a\u0646\u062f\u062a \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u0643\u0627\u0645\u0644\u0629 \u0639\u0644\u0649 \u0628\u064a\u0627\u0646\u0627\u062a \u0645\u0646 \u062b\u0644\u0627\u062b \u062a\u062c\u0627\u0631\u0628 \u0645\u062a\u0639\u062f\u062f\u0629 \u0627\u0644\u0645\u0631\u0627\u0643\u0632 \u0648\u063a\u064a\u0631 \u0639\u0634\u0648\u0627\u0626\u064a\u0629 \u0648\u0645\u0641\u062a\u0648\u062d\u0629 \u0627\u0644\u062a\u0633\u0645\u064a\u0629 \u0648\u0645\u062a\u0639\u062f\u062f\u0629 \u0627\u0644\u0623\u062a\u0631\u0627\u0628. \u0642\u0627\u0645 KEYNOTE-164 (NCT02460198) \u0628\u062a\u0633\u062c\u064a\u0644 124 \u0645\u0631\u064a\u0636\u064b\u0627 \u0645\u0635\u0627\u0628\u064b\u0627 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u0627\u0644\u0645\u062a\u0642\u062f\u0645 MSI-H\/dMMR \u0648\u0627\u0644\u0630\u064a\u0646 \u062a\u0642\u062f\u0645\u0648\u0627 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0641\u0644\u0648\u0631\u0648\u0628\u064a\u0631\u064a\u0645\u064a\u062f\u064a\u0646 \u0648\u0627\u0644\u0623\u0648\u0643\u0633\u0627\u0644\u064a\u0628\u0644\u0627\u062a\u064a\u0646 \u0623\u0648 \u0627\u0644\u0625\u0631\u064a\u0646\u0648\u062a\u064a\u0643\u0627\u0646\u060c \u0645\u0639 \u0623\u0648 \u0628\u062f\u0648\u0646 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0636\u0627\u062f \u0644\u0640 VEGF\/EGFR mAb. KEYNOTE-158 (NCT02628067) \u0642\u0627\u0645 \u0628\u062a\u0633\u062c\u064a\u0644 373 \u0645\u0631\u064a\u0636\u064b\u0627 \u0645\u0635\u0627\u0628\u064b\u0627 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u063a\u064a\u0631 \u0627\u0644\u0642\u0648\u0644\u0648\u0646\u064a \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u0627\u0644\u0645\u062a\u0642\u062f\u0645 MSI-H\/dMMR \u0648\u0627\u0644\u0630\u064a\u0646 \u0639\u0627\u0646\u0648\u0627 \u0645\u0646 \u062a\u0637\u0648\u0631 \u0627\u0644\u0645\u0631\u0636 \u0628\u0639\u062f \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0633\u0627\u0628\u0642. \u062a\u0645 \u062a\u0633\u062c\u064a\u0644 \u0627\u0644\u0645\u0631\u0636\u0649 \u0628\u0623\u062b\u0631 \u0631\u062c\u0639\u064a \u0645\u0639 \u0623\u0648\u0631\u0627\u0645 MSI-H \/ dMMR (\u0627\u0644\u0641\u0648\u062c K) \u0623\u0648 \u062a\u0645 \u062a\u062d\u062f\u064a\u062f\u0647\u0645 \u0628\u0623\u062b\u0631 \u0631\u062c\u0639\u064a \u0641\u064a \u0648\u0627\u062d\u062f\u0629 \u0645\u0646 10 \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0645\u0646 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0635\u0644\u0628\u0629 (\u0627\u0644\u0641\u0648\u062c AJ). KEYNOTE-051 (NCT02332668) \u0642\u0627\u0645 \u0628\u062a\u0633\u062c\u064a\u0644 \u0633\u0628\u0639\u0629 \u0645\u0631\u0636\u0649 \u0645\u0646 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0633\u0631\u0637\u0627\u0646 MSI-H\/dMMR. \u0627\u0633\u062a\u0628\u0639\u062f\u062a \u062c\u0645\u064a\u0639 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0645\u0646\u0627\u0639\u0629 \u0627\u0644\u0630\u0627\u062a\u064a\u0629 \u0623\u0648 \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u062a\u0637\u0644\u0628 \u0643\u0628\u062a \u0627\u0644\u0645\u0646\u0627\u0639\u0629. \u0628\u063a\u0636 \u0627\u0644\u0646\u0638\u0631 \u0639\u0646 \u0627\u0644\u0623\u0646\u0633\u062c\u0629\u060c \u062a\u0645 \u062a\u062d\u062f\u064a\u062f \u062d\u0627\u0644\u0629 \u0627\u0644\u0648\u0631\u0645 MSI \u0623\u0648 MMR \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062a\u0641\u0627\u0639\u0644 \u0627\u0644\u0628\u0644\u0645\u0631\u0629 \u0627\u0644\u0645\u062a\u0633\u0644\u0633\u0644 (\u0645\u062d\u0644\u064a \u0623\u0648 \u0645\u0631\u0643\u0632\u064a) \u0623\u0648 \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0621 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 (\u0645\u062d\u0644\u064a\u0629 \u0623\u0648 \u0645\u0631\u0643\u0632\u064a\u0629)\u060c \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a.<\/p>

\u062a\u0644\u0642\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0628\u0627\u0644\u063a\u064a\u0646 KEYTRUDA 200 \u0645\u0644\u063a \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0648\u0631\u064a\u062f \u0643\u0644 \u062b\u0644\u0627\u062b\u0629 \u0623\u0633\u0627\u0628\u064a\u0639 (\u062a\u0644\u0642\u0649 \u0645\u0631\u0636\u0649 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 2 \u0645\u0644\u063a\u0645 \/ \u0643\u063a\u0645 \u0643\u0644 \u062b\u0644\u0627\u062b\u0629 \u0623\u0633\u0627\u0628\u064a\u0639) \u062d\u062a\u0649 \u062d\u062f\u0648\u062b \u0633\u0645\u064a\u0629 \u063a\u064a\u0631 \u0645\u0642\u0628\u0648\u0644\u0629 \u0623\u0648 \u062a\u0637\u0648\u0631 \u0627\u0644\u0645\u0631\u0636 \u0623\u0648 \u0645\u0627 \u064a\u0635\u0644 \u0625\u0644\u0649 24 \u0634\u0647\u0631\u064b\u0627. \u0641\u064a KEYNOTE-164 \u0648KEYNOTE-158\u060c \u062a\u0645 \u062a\u0642\u064a\u064a\u0645 \u062d\u0627\u0644\u0629 \u0627\u0644\u0648\u0631\u0645 \u0643\u0644 9 \u0623\u0633\u0627\u0628\u064a\u0639 \u0644\u0644\u0633\u0646\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0648\u0643\u0644 12 \u0623\u0633\u0628\u0648\u0639\u064b\u0627 \u0628\u0639\u062f \u0630\u0644\u0643. \u0641\u064a KEYNOTE-051\u060c \u062a\u0645 \u0625\u062c\u0631\u0627\u0621 \u062a\u0642\u064a\u064a\u0645\u0627\u062a \u062d\u0627\u0644\u0629 \u0627\u0644\u0648\u0631\u0645 \u0643\u0644 \u062b\u0645\u0627\u0646\u064a\u0629 \u0623\u0633\u0627\u0628\u064a\u0639 \u0644\u0645\u062f\u0629 24 \u0623\u0633\u0628\u0648\u0639\u064b\u0627 \u0648\u0643\u0644 12 \u0623\u0633\u0628\u0648\u0639\u064b\u0627 \u0628\u0639\u062f \u0630\u0644\u0643. \u0643\u0627\u0646\u062a \u0645\u0642\u0627\u064a\u064a\u0633 \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0623\u0648\u0644\u064a\u0629 \u0647\u064a \u0645\u0639\u062f\u0644 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0645\u0648\u0636\u0648\u0639\u064a\u0629 (ORR) \u0648\u0645\u062f\u0629 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 (DOR)\u060c \u0643\u0645\u0627 \u062a\u0645 \u062a\u0642\u064a\u064a\u0645\u0647\u0627 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0645\u0631\u0627\u062c\u0639\u0629 \u0645\u0631\u0643\u0632\u064a\u0629 \u0645\u0633\u062a\u0642\u0644\u0629 \u0639\u0645\u064a\u0627\u0621 \u0648\u0641\u0642\u064b\u0627 \u0644\u0640 RECIST v1.1 (\u062a\u0645 \u062a\u0639\u062f\u064a\u0644\u0647\u0627 \u0644\u0645\u062a\u0627\u0628\u0639\u0629 10 \u0622\u0641\u0627\u062a \u0645\u0633\u062a\u0647\u062f\u0641\u0629 \u0643\u062d\u062f \u0623\u0642\u0635\u0649 \u06485 \u0622\u0641\u0627\u062a \u0645\u0633\u062a\u0647\u062f\u0641\u0629 \u0643\u062d\u062f \u0623\u0642\u0635\u0649 ) KEYNOTE- 158 \u0639\u0636\u0648\u064b\u0627) \u0648\u062a\u0645 \u062a\u0642\u064a\u064a\u0645\u0647\u0627 \u0645\u0646 \u0642\u0628\u0644 \u0627\u0644\u0628\u0627\u062d\u062b\u064a\u0646 \u0648\u0641\u0642\u064b\u0627 \u0644\u0640 RECIST v1.1 \u0641\u064a KEYNOTE-051.<\/p>

\u0641\u064a \u062a\u062d\u0644\u064a\u0644 \u0645\u062c\u0645\u0639 \u0644\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u062b\u0644\u0627\u062b\u060c \u0643\u0627\u0646 \u0644\u062f\u0649 KEYTRUDA \u0645\u0639\u062f\u0644 ORR \u0642\u062f\u0631\u0647 33.3% (95% CI\u060c 29.2-37.6)\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0645\u0639\u062f\u0644 \u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0643\u0627\u0645\u0644 \u0642\u062f\u0631\u0647 10.3% \u0648\u0645\u0639\u062f\u0644 \u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u062c\u0632\u0626\u064a \u0642\u062f\u0631\u0647 23.0%\u060c \u0645\u0639 \u0645\u062a\u0627\u0628\u0639\u0629 \u0645\u062a\u0648\u0633\u0637\u0629 \u0644\u0640 20.1 \u0634\u0647\u0631\u064b\u0627 (\u0627\u0644\u0645\u062f\u0649 \u0645\u0646 0.1 \u0625\u0644\u0649 71.4 \u0634\u0647\u0631\u064b\u0627). \u0645\u0646 \u0628\u064a\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0627\u0633\u062a\u062c\u0627\u0628\u0648\u0627 (\u0627\u0644\u0639\u062f\u062f = 168)\u060c \u062d\u0635\u0644 77% \u0645\u0646\u0647\u0645 \u0639\u0644\u0649 \u0627\u0633\u062a\u062c\u0627\u0628\u0627\u062a \u0627\u0633\u062a\u0645\u0631\u062a \u0644\u0645\u062f\u0629 12 \u0634\u0647\u0631\u064b\u0627 \u0623\u0648 \u0623\u0643\u062b\u0631\u060c \u064839% \u062d\u0635\u0644\u0648\u0627 \u0639\u0644\u0649 \u0627\u0633\u062a\u062c\u0627\u0628\u0627\u062a \u0627\u0633\u062a\u0645\u0631\u062a \u0644\u0645\u062f\u0629 36 \u0634\u0647\u0631\u064b\u0627 \u0623\u0648 \u0623\u0643\u062b\u0631. \u0643\u0627\u0646 \u0645\u062a\u0648\u0633\u0637 \u200b\u200bDOR 63.2 \u0634\u0647\u0631\u064b\u0627 (\u0627\u0644\u0645\u062f\u0649 \u0645\u0646 1.9+ \u0625\u0644\u0649 63.9+ \u0634\u0647\u0631\u064b\u0627).<\/p>

\u0641\u064a \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 MSI-H\/dMMR (\u0627\u0644\u0639\u062f\u062f = 124)\u060c \u0643\u0627\u0646 \u0644\u062f\u0649 KEYTRUDA \u0645\u0639\u062f\u0644 ORR \u0642\u062f\u0631\u0647 34% (95% CI\u060c 26%-43%) \u0648DOR \u064a\u062a\u0631\u0627\u0648\u062d \u0645\u0646 4.4 \u0625\u0644\u0649 58.5+ \u0634\u0647\u0631\u064b\u0627. \u0641\u064a \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0623\u0648\u0631\u0627\u0645 \u0635\u0644\u0628\u0629 \u0623\u062e\u0631\u0649 \u063a\u064a\u0631 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0627\u0644\u0645\u0633\u062a\u0642\u064a\u0645 MSI-H\/dMMR (\u0646 = 380)\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0633\u0631\u0637\u0627\u0646 \u0628\u0637\u0627\u0646\u0629 \u0627\u0644\u0631\u062d\u0645\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u0639\u062f\u0629 \u0623\u0648 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u0648\u0635\u0644 \u0627\u0644\u0645\u0639\u062f\u064a \u0627\u0644\u0645\u0631\u064a\u0626\u064a\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0627\u0644\u062f\u0642\u064a\u0642\u0629\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062f\u0645\u0627\u063a\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u0628\u064a\u0636\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0646\u0627\u0629 \u0627\u0644\u0635\u0641\u0631\u0627\u0648\u064a\u0629\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633\u060c \u0648\u0633\u0631\u0637\u0627\u0646\u060c \u0633\u0627\u0631\u0643\u0648\u0645\u0627\u060c \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0639\u0646\u0642 \u0627\u0644\u0631\u062d\u0645\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u063a\u062f\u062f \u0627\u0644\u0635\u0645 \u0627\u0644\u0639\u0635\u0628\u064a\u0629\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0631\u0648\u0633\u062a\u0627\u062a\u0627\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0642\u0634\u0631\u0629 \u0627\u0644\u0643\u0638\u0631\u060c \u0648\u0631\u0645 \u0627\u0644\u0638\u0647\u0627\u0631\u0629 \u0627\u0644\u0645\u062a\u0648\u0633\u0637\u0629\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0631\u0626\u0629 \u0630\u0648 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0635\u063a\u064a\u0631\u0629\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u062b\u0627\u0646\u0629\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u063a\u062f\u062f \u0627\u0644\u0644\u0639\u0627\u0628\u064a\u0629\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0643\u0644\u0648\u064a\u0629 \u0648\u063a\u064a\u0631\u0647\u0627 \u0645\u0646 \u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0633\u0631\u0637\u0627\u0646 (\u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0634\u0631\u062c\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0631\u0623\u0633 \u0648\u0627\u0644\u0631\u0642\u0628\u0629\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062d\u0631\u0634\u0641\u064a\u0629\u060c \u0648\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0644\u0639\u0648\u0645 \u0627\u0644\u0623\u0646\u0641\u064a). \u0633\u0631\u0637\u0627\u0646)\u060c \u0633\u0631\u0637\u0627\u0646 \u062e\u0644\u0641 \u0627\u0644\u0635\u0641\u0627\u0642\u060c \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062e\u0635\u064a\u0629\u060c \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u0647\u0628\u0644\u060c \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0641\u0631\u062c\u060c \u0633\u0631\u0637\u0627\u0646 \u063a\u062f\u064a \u0627\u0644\u0632\u0627\u0626\u062f\u0629 \u0627\u0644\u062f\u0648\u062f\u064a\u0629\u060c \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0643\u0628\u062f\u064a\u0629\u060c<\/p>

\u0641\u064a KEYNOTE-158 \u0648KEYNOTE-164\u060c \u0643\u0627\u0646 \u0645\u062a\u0648\u0633\u0637 \u200b\u200b\u0645\u062f\u0629 \u0627\u0644\u062a\u0639\u0631\u0636 \u0644\u0640 KEYTRUDA 6.2 \u0634\u0647\u0631\u064b\u0627 (\u0627\u0644\u0645\u062f\u0649 \u0645\u0646 \u064a\u0648\u0645 \u0648\u0627\u062d\u062f \u0625\u0644\u0649 53.5 \u0634\u0647\u0631\u064b\u0627). \u0641\u064a KEYNOTE-051\u060c \u0643\u0627\u0646 \u0645\u062a\u0648\u0633\u0637 \u200b\u200b\u0645\u062f\u0629 \u0627\u0644\u062a\u0639\u0631\u0636 2.1 \u0634\u0647\u0631\u064b\u0627 (\u0627\u0644\u0646\u0637\u0627\u0642: \u064a\u0648\u0645 \u0648\u0627\u062d\u062f \u0625\u0644\u0649 25 \u0634\u0647\u0631\u064b\u0627).<\/p>

\u0643\u064a\u062a\u0631\u0648\u062f\u0627 (\u0628\u064a\u0645\u0628\u0631\u0648\u0644\u064a\u0632\u0648\u0645\u0627\u0628) \u0647\u0648 \u0639\u0644\u0627\u062c \u0645\u0636\u0627\u062f \u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0645\u0648\u062a \u0627\u0644\u0645\u0628\u0631\u0645\u062c -1 (PD-1) \u064a\u0639\u0645\u0644 \u0639\u0646 \u0637\u0631\u064a\u0642 \u062a\u062d\u0633\u064a\u0646 \u0642\u062f\u0631\u0629 \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0646\u0627\u0639\u064a \u0641\u064a \u0627\u0644\u062c\u0633\u0645 \u0639\u0644\u0649 \u0627\u0644\u0645\u0633\u0627\u0639\u062f\u0629 \u0641\u064a \u0627\u0643\u062a\u0634\u0627\u0641 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629 \u0648\u0645\u0643\u0627\u0641\u062d\u062a\u0647\u0627. KEYTRUDA \u0647\u0648 \u062c\u0633\u0645 \u0645\u0636\u0627\u062f \u0623\u062d\u0627\u062f\u064a \u0627\u0644\u0646\u0633\u064a\u0644\u0629 \u0645\u062a\u0648\u0627\u0641\u0642 \u0645\u0639 \u0627\u0644\u0628\u0634\u0631\u060c \u064a\u0645\u0646\u0639 \u0627\u0644\u062a\u0641\u0627\u0639\u0644 \u0628\u064a\u0646 PD-1 \u0648\u0631\u0648\u0627\u0628\u0637\u0647 PD-L1 \u0648PD-L2\u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a \u062a\u0646\u0634\u064a\u0637 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0644\u064a\u0645\u0641\u0627\u0648\u064a\u0629 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0627\u0644\u062a\u064a \u0642\u062f \u062a\u0624\u062b\u0631 \u0639\u0644\u0649 \u0643\u0644 \u0645\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629 \u0648\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0644\u064a\u0645\u0629.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

29 \u0645\u0627\u0631\u0633 2023 (\u0644\u0648\u064a\u060c \u0646\u064a\u0648\u062c\u064a\u0631\u0633\u064a) \u0634\u0631\u0643\u0629 Merck &…<\/p>\n","protected":false},"author":1,"featured_media":10824,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[1],"tags":[],"class_list":["post-10823","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"https:\/\/tycoon-asia.com\/wp-content\/uploads\/2024\/06\/Frj_yarZsK5VgTPYo74rWmEZGrCw-1-768x768-1.webp","_links":{"self":[{"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=\/wp\/v2\/posts\/10823","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=10823"}],"version-history":[{"count":4,"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=\/wp\/v2\/posts\/10823\/revisions"}],"predecessor-version":[{"id":10828,"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=\/wp\/v2\/posts\/10823\/revisions\/10828"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=\/wp\/v2\/media\/10824"}],"wp:attachment":[{"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=10823"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=10823"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tycoon-asia.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=10823"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}