{"id":10358,"date":"2024-06-28T03:10:08","date_gmt":"2024-06-28T03:10:08","guid":{"rendered":"https:\/\/tycoon-asia.com\/?post_type=product&#038;p=10358"},"modified":"2024-07-01T01:12:09","modified_gmt":"2024-07-01T01:12:09","slug":"sunvozertinib-tablets","status":"publish","type":"product","link":"https:\/\/tycoon-asia.com\/?product=sunvozertinib-tablets","title":{"rendered":"\u0623\u0642\u0631\u0627\u0635 \u0633\u0648\u0646\u0641\u0648\u0632\u064a\u0631\u062a\u064a\u0646\u064a\u0628"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"<p>\u0623\u0642\u0631\u0627\u0635 Suvotinib (DZD9008 [1]\u060c \u0627\u0644\u0627\u0633\u0645 \u0627\u0644\u062a\u062c\u0627\u0631\u064a: Suvozhe) \u0647\u064a \u0623\u0648\u0644 \u062f\u0648\u0627\u0621 \u062c\u062f\u064a\u062f \u064a\u0633\u062a\u0647\u062f\u0641 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0631\u0626\u0629 \u062a\u0645 \u062a\u0637\u0648\u064a\u0631\u0647 \u0628\u0634\u0643\u0644 \u0645\u0633\u062a\u0642\u0644 \u0628\u0648\u0627\u0633\u0637\u0629 \u0634\u0631\u0643\u0629 Digene Pharmaceuticals [2]. \u0648\u0647\u0648 \u0645\u062b\u0628\u0637 EGFR \u062a\u064a\u0631\u0648\u0632\u064a\u0646 \u0643\u064a\u0646\u0627\u0632 (TKI) \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0641\u0645\u060c \u0644\u0627 \u0631\u062c\u0639\u0629 \u0641\u064a\u0647\u060c \u0627\u0646\u062a\u0642\u0627\u0626\u064a \u0644\u0644\u063a\u0627\u064a\u0629 \u0648\u064a\u0633\u062a\u0647\u062f\u0641 \u0623\u0646\u0648\u0627\u0639\u064b\u0627 \u0641\u0631\u0639\u064a\u0629 \u0645\u062a\u0639\u062f\u062f\u0629 \u0645\u0646 \u0637\u0641\u0631\u0629 EGFR [3].<br \/>\n\u062a\u0645\u062a \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 \u062f\u0648\u0627\u0621 Suvotinib \u0644\u0623\u0648\u0644 \u0645\u0631\u0629 \u0641\u064a \u0627\u0644\u0635\u064a\u0646 \u0641\u064a 22 \u0623\u063a\u0633\u0637\u0633 2023 [3]\u060c \u0644\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0631\u0626\u0629 \u0630\u0648 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u063a\u064a\u0631 \u0627\u0644\u0635\u063a\u064a\u0631\u0629 \u0627\u0644\u0645\u062a\u0642\u062f\u0645 \u0645\u062d\u0644\u064a\u064b\u0627 \u0623\u0648 \u0627\u0644\u0646\u0642\u064a\u0644\u064a (NSCLC) \u0648\u0627\u0644\u0630\u064a\u0646 \u0633\u0628\u0642 \u0644\u0647\u0645 \u0623\u0646 \u0639\u0627\u0646\u0648\u0627 \u0645\u0646 \u062a\u0637\u0648\u0631 \u0627\u0644\u0645\u0631\u0636 \u0628\u0639\u062f \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0627\u0644\u0645\u062d\u062a\u0648\u064a \u0639\u0644\u0649 \u0627\u0644\u0628\u0644\u0627\u062a\u064a\u0646\u060c \u0623\u0648 \u0644\u0627 \u064a\u062a\u062d\u0645\u0644\u0648\u0646 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0627\u0644\u0645\u062d\u062a\u0648\u064a \u0639\u0644\u0649 \u0627\u0644\u0628\u0644\u0627\u062a\u064a\u0646. \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0627\u0644\u0645\u062d\u062a\u0648\u064a \u0639\u0644\u0649 \u0627\u0644\u0628\u0644\u0627\u062a\u064a\u0646\u060c \u0648\u062a\u0645 \u0627\u0644\u062a\u0623\u0643\u062f \u0645\u0646 \u0648\u062c\u0648\u062f \u0637\u0641\u0631\u0627\u062a \u0625\u062f\u062e\u0627\u0644 EGFR exon 20 [4].<br \/>\nSuvotinib \u0647\u0648 \u0623\u0648\u0644 \u062f\u0648\u0627\u0621 \u062c\u062f\u064a\u062f \u0635\u064a\u0646\u064a \u0623\u0635\u0644\u064a \u0645\u0646 \u0627\u0644\u062f\u0631\u062c\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0644\u0639\u0644\u0627\u062c \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0631\u0626\u0629 \u063a\u064a\u0631 \u0635\u063a\u064a\u0631 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u062a\u0642\u062f\u0645 \u0645\u0639 \u0637\u0641\u0631\u0627\u062a EGFR Exon20ins [5]. \u0625\u0646\u0647 \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0635\u064a\u0646\u064a \u0627\u0644\u0645\u0628\u062a\u0643\u0631 \u0627\u0644\u0623\u0648\u0644 \u0648\u0627\u0644\u0648\u062d\u064a\u062f \u0641\u064a \u0645\u062c\u0627\u0644 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0631\u0626\u0629 \u0627\u0644\u0630\u064a \u062a\u0645 \u0627\u0644\u0627\u0639\u062a\u0631\u0627\u0641 \u0628\u0647 \u0643\u0639\u0644\u0627\u062c \u0645\u062a\u0637\u0648\u0631 \u0645\u0646 \u0642\u0628\u0644 \u0627\u0644\u0633\u0644\u0637\u0627\u062a \u0627\u0644\u062a\u0646\u0638\u064a\u0645\u064a\u0629 \u0644\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0635\u064a\u0646\u064a\u0629 \u0648\u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 [1].<br \/>\n\u0623\u0638\u0647\u0631\u062a \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062a\u062c\u0631\u0628\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u0635\u064a\u0646\u064a\u0629 \u0627\u0644\u0645\u0633\u062c\u0644\u0629 (WU-KONG6) \u0623\u0646\u0647\u0627 &#8220;\u0641\u0639\u0627\u0644\u0629 \u0644\u0644\u063a\u0627\u064a\u0629\u060c \u0648\u0645\u0646\u062e\u0641\u0636\u0629 \u0627\u0644\u0633\u0645\u064a\u0629\u060c \u0648\u0631\u0628\u0645\u0627 \u0627\u0644\u0623\u0641\u0636\u0644 \u0641\u064a \u0641\u0626\u062a\u0647\u0627&#8221;: \u0646\u0642\u0637\u0629 \u0627\u0644\u0646\u0647\u0627\u064a\u0629 \u0627\u0644\u0623\u0648\u0644\u064a\u0629 \u0644\u0645\u0639\u062f\u0644 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0645\u0648\u0636\u0648\u0639\u064a\u0629 (ORR) \u0627\u0644\u062a\u064a \u062a\u0645 \u062a\u0642\u064a\u064a\u0645\u0647\u0627 \u0645\u0646 \u0642\u0628\u0644 \u0644\u062c\u0646\u0629 \u0645\u0631\u0627\u062c\u0639\u0629 \u0627\u0644\u062a\u0635\u0648\u064a\u0631 \u0627\u0644\u0645\u0633\u062a\u0642\u0644\u0629 ( IRC) \u0648\u0635\u0644\u062a \u0625\u0644\u0649 60.8%\u060c \u0648\u0647\u0648 \u0623\u0639\u0644\u0649 \u0645\u0646 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\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u063a\u064a\u0631 \u0627\u0644\u0635\u063a\u064a\u0631\u0629 (NSCLC) \u0627\u0644\u0645\u062a\u0642\u062f\u0645 \u0645\u062d\u0644\u064a\u064b\u0627 \u0623\u0648 \u0627\u0644\u0646\u0642\u064a\u0644\u064a \u0648\u0627\u0644\u0630\u064a\u0646 \u0639\u0627\u0646\u0648\u0627 \u0645\u0646 \u062a\u0637\u0648\u0631 \u0627\u0644\u0645\u0631\u0636 \u0623\u062b\u0646\u0627\u0621 \u0623\u0648 \u0628\u0639\u062f \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0627\u0644\u0645\u062d\u062a\u0648\u064a \u0639\u0644\u0649 \u0627\u0644\u0628\u0644\u0627\u062a\u064a\u0646\u060c \u0623\u0648 \u0627\u0644\u0630\u064a\u0646 \u0644\u0627 \u064a\u062a\u062d\u0645\u0644\u0648\u0646 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0627\u0644\u0645\u062d\u062a\u0648\u064a \u0639\u0644\u0649 \u0627\u0644\u0628\u0644\u0627\u062a\u064a\u0646\u060c \u0648\u062a\u0645 \u0627\u0644\u062a\u0623\u0643\u062f \u0645\u0646 \u0625\u0635\u0627\u0628\u062a\u0647\u0645 \u0628\u0627\u0644\u062c\u0644\u062f. \u0645\u0633\u062a\u0642\u0628\u0644 \u0639\u0627\u0645\u0644 \u0627\u0644\u0646\u0645\u0648 (EGFR) \u0625\u0643\u0633\u0648\u0646 20 \u0637\u0641\u0631\u0627\u062a \u0627\u0644\u0625\u062f\u0631\u0627\u062c 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