{"id":10362,"date":"2024-06-28T03:10:08","date_gmt":"2024-06-28T03:10:08","guid":{"rendered":"https:\/\/tycoon-asia.com\/?post_type=product&#038;p=10362"},"modified":"2024-07-01T01:11:30","modified_gmt":"2024-07-01T01:11:30","slug":"ivosidenib-tablets","status":"publish","type":"product","link":"https:\/\/tycoon-asia.com\/?product=ivosidenib-tablets","title":{"rendered":"\u0623\u0642\u0631\u0627\u0635 \u0625\u064a\u0641\u0648\u0633\u064a\u062f\u064a\u0646\u064a\u0628"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"<p>Ivosidenib (\u0627\u0644\u0627\u0633\u0645 \u0627\u0644\u062a\u062c\u0627\u0631\u064a Tosuvo\u00ae [4]) \u0647\u0648 \u0623\u0648\u0644 \u062f\u0648\u0627\u0621 \u0645\u0639\u062a\u0645\u062f \u0641\u064a \u0627\u0644\u0635\u064a\u0646 [4]\u060c \u0648\u0647\u0648 \u0645\u062b\u0628\u0637 \u0642\u0648\u064a \u0645\u0633\u062a\u0647\u062f\u0641 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0641\u0645 \u0644\u0633\u0631\u0637\u0627\u0646\u0627\u062a \u0637\u0641\u0631\u0629 \u0625\u064a\u0632\u0648\u0633\u064a\u062a\u0631\u0627\u062a \u062f\u064a\u0647\u064a\u062f\u0631\u0648\u062c\u064a\u0646\u064a\u0632 -1 (IDH1) [2]. \u062a\u0645 \u062a\u0637\u0648\u064a\u0631\u0647\u0627 \u0641\u064a \u0627\u0644\u0623\u0635\u0644 \u0628\u0648\u0627\u0633\u0637\u0629 \u0634\u0631\u0643\u0629 Agios Pharmaceuticals\u060c \u0648\u062a\u0648\u0635\u0644\u062a \u0634\u0631\u0643\u0629 CStone Pharmaceuticals \u0648Agios \u0625\u0644\u0649 \u0627\u062a\u0641\u0627\u0642\u064a\u0629 \u062a\u0637\u0648\u064a\u0631 \u0648\u062a\u0633\u0648\u064a\u0642 \u062d\u0635\u0631\u064a\u0629 \u0641\u064a \u0627\u0644\u0635\u064a\u0646 \u0627\u0644\u0643\u0628\u0631\u0649 \u0641\u064a \u0639\u0627\u0645 2018\u060c \u0648\u0648\u0633\u0639\u062a \u0645\u0646\u0637\u0642\u0629 \u062a\u0631\u062e\u064a\u0635 \u0627\u0644\u062a\u0637\u0648\u064a\u0631 \u0648\u0627\u0644\u062a\u0633\u0648\u064a\u0642 \u0627\u0644\u0633\u0631\u064a\u0631\u064a \u0645\u0646 \u0627\u0644\u0635\u064a\u0646 \u0627\u0644\u0643\u0628\u0631\u0649 \u0625\u0644\u0649 \u0633\u0646\u063a\u0627\u0641\u0648\u0631\u0629 \u0641\u064a \u0639\u0627\u0645 2020.[3]<br \/>\n\u0641\u064a 9 \u0641\u0628\u0631\u0627\u064a\u0631 2022\u060c \u0648\u0627\u0641\u0642\u062a \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u0645\u0646\u062a\u062c\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0629 \u0627\u0644\u0648\u0637\u0646\u064a\u0629 \u0627\u0644\u0635\u064a\u0646\u064a\u0629 (NMPA) \u0639\u0644\u0649 \u062a\u0637\u0628\u064a\u0642 \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u062c\u062f\u064a\u062f \u0644\u0640 ivosidenib\u060c \u0648\u0647\u0648 \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0648\u0644 \u0641\u064a \u0641\u0626\u062a\u0647 [6]. \u0647\u0630\u0627 \u0627\u0644\u062f\u0648\u0627\u0621 \u0647\u0648 \u0623\u0648\u0644 \u0645\u062b\u0628\u0637 \u0644\u0640 IDH1 \u0645\u0639\u062a\u0645\u062f \u0641\u064a \u0627\u0644\u0635\u064a\u0646\u060c \u0648\u064a\u0633\u062a\u062e\u062f\u0645 \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0628\u0627\u0644\u063a\u064a\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062f\u0645 \u0627\u0644\u0646\u062e\u0627\u0639\u064a \u0627\u0644\u062d\u0627\u062f \u0627\u0644\u0627\u0646\u062a\u0643\u0627\u0633 \u0623\u0648 \u0627\u0644\u0645\u0642\u0627\u0648\u0645 (R\/R AML) \u0627\u0644\u0630\u064a \u064a\u062d\u0645\u0644 \u0637\u0641\u0631\u0627\u062a \u062d\u0633\u0627\u0633\u0629 \u0644\u0640 IDH1. 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