\u0623\u0645\u064a\u0641\u0627\u0646\u062a\u0627\u0645\u0627\u0628 \u0647\u0648 \u062c\u0633\u0645 \u0645\u0636\u0627\u062f \u062b\u0646\u0627\u0626\u064a \u0627\u0644\u062a\u062e\u0635\u0635 \u064a\u0633\u062a\u0647\u062f\u0641 \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0639\u0627\u0645\u0644 \u0646\u0645\u0648 \u0627\u0644\u0628\u0634\u0631\u0629 (EGFR)\/c-Met\u060c \u0648\u064a\u064f\u0633\u062a\u062e\u062f\u0645 \u0628\u0634\u0643\u0644 \u0631\u0626\u064a\u0633\u064a \u0644\u0639\u0644\u0627\u062c \u0645\u0631\u0636\u0649 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0631\u0626\u0629 \u0630\u0648 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u063a\u064a\u0631 \u0627\u0644\u0635\u063a\u064a\u0631\u0629 \u0627\u0644\u0645\u062a\u0642\u062f\u0645 (NSCLC) \u0627\u0644\u062d\u0627\u0645\u0644\u064a\u0646 \u0644\u0637\u0641\u0631\u0627\u062a \u0625\u062f\u062e\u0627\u0644 \u0625\u0643\u0633\u0648\u0646 20 \u0641\u064a EGFR. \u064a\u062b\u0628\u0637 \u0647\u0630\u0627 \u0627\u0644\u062f\u0648\u0627\u0621 \u0646\u0645\u0648 \u0627\u0644\u0648\u0631\u0645 \u0639\u0646 \u0637\u0631\u064a\u0642 \u062d\u062c\u0628 \u0645\u0633\u0627\u0631\u0627\u062a \u0625\u0634\u0627\u0631\u0627\u062a EGFR \u0648c-Met \u0641\u064a \u0622\u0646\u064d \u0648\u0627\u062d\u062f\u060c \u0648\u0647\u0648 \u0645\u0646\u0627\u0633\u0628 \u0644\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0637\u0641\u0631\u0627\u062a \u0645\u062d\u062f\u062f\u0629 \u0648\u0627\u0644\u0630\u064a\u0646 \u064a\u062a\u0637\u0648\u0631 \u0645\u0631\u0636\u0647\u0645 \u0628\u0639\u062f \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0628\u0627\u0644\u0628\u0644\u0627\u062a\u064a\u0646. \u064a\u062c\u0628 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0647\u0630\u0627 \u0627\u0644\u062f\u0648\u0627\u0621 \u062a\u062d\u062a \u0625\u0634\u0631\u0627\u0641 \u0637\u0628\u064a\u060c \u0648\u0642\u062f \u064a\u0633\u0628\u0628 \u0622\u062b\u0627\u0631\u064b\u0627 \u062c\u0627\u0646\u0628\u064a\u0629 \u0645\u062b\u0644 \u0627\u0644\u0637\u0641\u062d \u0627\u0644\u062c\u0644\u062f\u064a \u0648\u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0627\u0644\u062a\u0633\u0631\u064a\u0628\u060c \u0648\u0627\u0644\u062a\u064a \u062a\u062a\u0637\u0644\u0628 \u0645\u0631\u0627\u0642\u0628\u0629 \u062f\u0642\u064a\u0642\u0629.<\/p>\n
\u0622\u0644\u064a\u0629 \u0627\u0644\u0639\u0645\u0644 \u0648\u062f\u0648\u0627\u0639\u064a \u0627\u0644\u0627\u0633\u062a\u0639\u0645\u0627\u0644<\/p>\n
\u0622\u0644\u064a\u0629 \u0627\u0644\u0639\u0645\u0644: \u064a\u0631\u062a\u0628\u0637 \u0623\u0645\u064a\u0641\u0627\u0646\u062a\u0627\u0645\u0627\u0628 \u0628\u0628\u0631\u0648\u062a\u064a\u0646\u064a EGFR \u0648c-Met\u060c \u0648\u064a\u0645\u0646\u0639 \u0627\u0646\u062a\u0642\u0627\u0644 \u0627\u0644\u0625\u0634\u0627\u0631\u0629 \u0627\u0644\u0644\u0627\u062d\u0642\u0629\u060c \u0648\u064a\u0645\u0646\u0639 \u062a\u0643\u0627\u062b\u0631 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629\u060c \u0648\u064a\u062d\u0641\u0632 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0639\u0644\u0649 \u0642\u062a\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629.<\/p>\n
\u062f\u0648\u0627\u0639\u064a \u0627\u0644\u0627\u0633\u062a\u0639\u0645\u0627\u0644: \u064a\u064f\u0633\u062a\u062e\u062f\u0645 \u0628\u0634\u0643\u0644 \u0631\u0626\u064a\u0633\u064a \u0644\u0645\u0631\u0636\u0649 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0631\u0626\u0629 \u0630\u0648 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u063a\u064a\u0631 \u0627\u0644\u0635\u063a\u064a\u0631\u0629 \u0627\u0644\u0645\u062a\u0642\u062f\u0645 \u0645\u0639 \u0637\u0641\u0631\u0627\u062a \u0641\u064a \u0625\u062f\u062e\u0627\u0644 \u0625\u0643\u0633\u0648\u0646 20 \u0644\u0645\u0633\u062a\u0642\u0628\u0644 \u0639\u0627\u0645\u0644 \u0646\u0645\u0648 \u0627\u0644\u0628\u0634\u0631\u0629 (EGFR)\u060c \u0643\u062e\u064a\u0627\u0631 \u0639\u0644\u0627\u062c\u064a \u0645\u0646 \u0627\u0644\u062e\u0637 \u0627\u0644\u062b\u0627\u0646\u064a (\u0623\u064a \u0628\u0639\u062f \u0641\u0634\u0644 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0628\u0627\u0644\u0628\u0644\u0627\u062a\u064a\u0646).<\/p>\n
\u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0648\u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a<\/p>\n
\u0623\u0638\u0647\u0631\u062a \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0641\u0639\u0627\u0644\u064a\u0629 \u0643\u0628\u064a\u0631\u0629 \u0644\u0625\u064a\u0641\u0627\u0646\u062a\u0648\u0645\u0627\u0628 \u0644\u062f\u0649 \u0627\u0644\u0641\u0626\u0629 \u0627\u0644\u0645\u0633\u062a\u0647\u062f\u0641\u0629:<\/p>\n
\u064a\u0628\u0644\u063a \u0645\u0639\u062f\u0644 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0645\u0648\u0636\u0648\u0639\u064a\u0629 (ORR) \u062d\u0648\u0627\u0644\u064a 40%\u060c \u0648\u0645\u062a\u0648\u0633\u0637 \u200b\u200b\u0645\u062f\u0629 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 (DOR) 11.1 \u0634\u0647\u0631\u064b\u0627\u061b<\/p>\n
\u064a\u0628\u0644\u063a \u0645\u062a\u0648\u0633\u0637 \u200b\u200b\u0627\u0644\u0628\u0642\u0627\u0621 \u0639\u0644\u0649 \u0642\u064a\u062f \u0627\u0644\u062d\u064a\u0627\u0629 \u062f\u0648\u0646 \u062a\u0637\u0648\u0631 \u0627\u0644\u0645\u0631\u0636 (PFS) 8.3 \u0634\u0647\u0631\u064b\u0627\u060c \u0648\u0647\u0648 \u0623\u0643\u062b\u0631 \u0641\u0627\u0626\u062f\u0629 \u0645\u0646 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0627\u0644\u062a\u0642\u0644\u064a\u062f\u064a.<\/p>\n
\u0627\u0644\u0622\u062b\u0627\u0631 \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629 \u0627\u0644\u0634\u0627\u0626\u0639\u0629 \u0648\u0627\u0644\u0639\u0644\u0627\u062c<\/p>\n
\u0627\u0644\u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0627\u0644\u062c\u0644\u062f\u064a\u0629: \u064a\u064f\u0635\u0627\u0628 \u062d\u0648\u0627\u0644\u064a 86% \u0645\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0628\u0637\u0641\u062d \u062c\u0644\u062f\u064a\u060c \u0648\u0627\u0644\u0630\u064a \u064a\u0645\u0643\u0646 \u062a\u062e\u0641\u064a\u0641\u0647 \u0628\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0648\u0636\u0639\u064a \u0623\u0648 \u062a\u0639\u062f\u064a\u0644 \u0627\u0644\u062c\u0631\u0639\u0629\u061b<\/p>\n
\u0627\u0644\u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0627\u0644\u062a\u0633\u0631\u064a\u0628: \u062a\u0628\u0644\u063a \u0646\u0633\u0628\u0629 \u062d\u062f\u0648\u062b\u0647\u0627 \u062d\u0648\u0627\u0644\u064a 66%\u060c \u0648\u064a\u062c\u0628 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u062d\u0633\u0627\u0633\u064a\u0629 \u0642\u0628\u0644 \u0627\u0644\u0639\u0644\u0627\u062c \u0644\u0644\u0648\u0642\u0627\u064a\u0629 \u0645\u0646\u0647\u0627\u061b<\/p>\n
\u0622\u062b\u0627\u0631 \u062c\u0627\u0646\u0628\u064a\u0629 \u0623\u062e\u0631\u0649: \u062a\u0634\u0645\u0644 \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0638\u0641\u0631\u060c \u0648\u0642\u0631\u062d \u0627\u0644\u0641\u0645\u060c \u0648\u0646\u0642\u0635 \u0623\u0644\u0628\u0648\u0645\u064a\u0646 \u0627\u0644\u062f\u0645\u060c \u0648\u063a\u064a\u0631\u0647\u0627.<\/p>\n
\u0627\u062d\u062a\u064a\u0627\u0637\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0621<\/p>\n
\u0627\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062d\u0633\u0628 \u062a\u0648\u062c\u064a\u0647\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0628: \u0627\u0644\u062a\u0632\u0645 \u0628\u062f\u0642\u0629 \u0628\u0627\u0644\u062c\u0631\u0639\u0629 \u0648\u062f\u0648\u0631\u0629 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062a\u064a \u0648\u0635\u0641\u0647\u0627 \u0627\u0644\u0637\u0628\u064a\u0628\u060c \u0648\u0644\u0627 \u062a\u064f\u0639\u062f\u0650\u0651\u0644 \u0623\u0648 \u062a\u0648\u0642\u0641 \u0627\u0644\u062f\u0648\u0627\u0621 \u0645\u0646 \u062a\u0644\u0642\u0627\u0621 \u0646\u0641\u0633\u0643.<\/p>\n
\u0627\u0644\u0645\u0631\u0627\u0642\u0628\u0629 \u0648\u0627\u0644\u062a\u062f\u062e\u0644: \u0627\u0641\u062d\u0635 \u0648\u0638\u0627\u0626\u0641 \u0627\u0644\u0643\u0628\u062f\u060c \u0648\u0627\u0644\u0643\u0647\u0627\u0631\u0644\u060c \u0648\u062d\u0627\u0644\u0629 \u0627\u0644\u0631\u0626\u0629 \u0628\u0627\u0646\u062a\u0638\u0627\u0645 \u0623\u062b\u0646\u0627\u0621 \u0627\u0644\u0639\u0644\u0627\u062c (\u0644\u0623\u0646\u0647 \u0642\u062f \u064a\u064f\u0633\u0628\u0628 \u0645\u0631\u0636 \u0627\u0644\u0631\u0626\u0629 \u0627\u0644\u062e\u0644\u0627\u0644\u064a).<\/p>\n
\u0645\u0648\u0627\u0646\u0639 \u0627\u0644\u0627\u0633\u062a\u0639\u0645\u0627\u0644: \u064a\u064f\u0645\u0646\u0639 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647 \u0644\u0645\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u062d\u0633\u0627\u0633\u064a\u0629 \u062a\u062c\u0627\u0647 \u0645\u0643\u0648\u0646\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0621\u060c \u0648\u0639\u0644\u0649 \u0627\u0644\u0646\u0633\u0627\u0621 \u0627\u0644\u062d\u0648\u0627\u0645\u0644 \u0623\u0648 \u0627\u0644\u0645\u0631\u0636\u0639\u0627\u062a \u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0645\u062e\u0627\u0637\u0631.<\/p>\n
\u0627\u0644\u0625\u0631\u0634\u0627\u062f\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0629 \u0644\u0644\u0645\u0631\u064a\u0636<\/p>\n
\u064a\u062a\u0637\u0644\u0628 \u062a\u0623\u0643\u064a\u062f \u0648\u062c\u0648\u062f \u0637\u0641\u0631\u0629 \u0641\u064a \u062c\u064a\u0646 EGFR exon 20 \u0625\u062c\u0631\u0627\u0621 \u0641\u062d\u0635 \u062c\u064a\u0646\u064a.<\/p>\n
\u0625\u0630\u0627 \u062a\u0637\u0648\u0631 \u0627\u0644\u0645\u0631\u0636 \u0628\u0639\u062f \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u060c \u064a\u064f\u0645\u0643\u0646\u0643 \u0625\u062d\u0636\u0627\u0631 \u062a\u0642\u0631\u064a\u0631 \u0627\u0644\u0641\u062d\u0635 \u0625\u0644\u0649 \u0639\u064a\u0627\u062f\u0629 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0645\u062a\u062e\u0635\u0635\u0629 \u0644\u0644\u062a\u0642\u064a\u064a\u0645.<\/p>\n
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