\u062a\u0627\u0631\u0644\u0627\u062a\u0627\u0645\u0627\u0628 \u062f\u0648\u0627\u0621\u064c \u0645\u0636\u0627\u062f\u064c\u0651 \u062b\u0646\u0627\u0626\u064a\u064f\u0651 \u0627\u0644\u062a\u062e\u0635\u0635 \u064a\u0633\u062a\u0647\u062f\u0641 \u0628\u0631\u0648\u062a\u064a\u0646 DLL3 \u0648\u0645\u0633\u062a\u0642\u0628\u0644 CD3\u060c \u0648\u064a\u064f\u0633\u062a\u062e\u062f\u0645 \u0628\u0634\u0643\u0644\u064d \u0631\u0626\u064a\u0633\u064a\u064d\u0651 \u0644\u0639\u0644\u0627\u062c \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0631\u0626\u0629 \u0635\u063a\u064a\u0631 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 (SCLC)\u060c \u0648\u062e\u0627\u0635\u0629\u064b \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0627\u0646\u062a\u0643\u0627\u0633\u0627\u062a\u064d \u0623\u0648 \u0645\u0642\u0627\u0648\u0645\u0627\u062a\u064d \u0644\u0644\u0639\u0644\u0627\u062c. \u064a\u064f\u0646\u0634\u0650\u0651\u0637 \u0647\u0630\u0627 \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0644\u0644\u062a\u0639\u0631\u0641 \u0639\u0644\u0649 \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0648\u0631\u0645 \u0627\u0644\u0645\u064f\u0639\u0628\u0650\u0651\u0631\u0629 \u0639\u0646 DLL3 \u0648\u0642\u062a\u0644\u0647\u0627\u060c \u0648\u064a\u0646\u062a\u0645\u064a \u0625\u0644\u0649 \u0639\u0644\u0627\u062c \u0645\u064f\u0646\u0634\u0650\u0651\u0637 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u062b\u0646\u0627\u0626\u064a\u064f\u0651 \u0627\u0644\u062a\u062e\u0635\u0635 (BiTE). \u064a\u062e\u0636\u0639 \u0627\u0644\u062f\u0648\u0627\u0621 \u062d\u0627\u0644\u064a\u064b\u0627 \u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629\u060c \u0648\u0644\u0645 \u064a\u064f\u0639\u062a\u0645\u062f \u0628\u0639\u062f\u064f \u0644\u0644\u062a\u0633\u0648\u064a\u0642 \u0639\u0627\u0644\u0645\u064a\u064b\u0627. \u064a\u062c\u0628 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647 \u0628\u062f\u0642\u0629\u064d \u062a\u062d\u062a \u0625\u0634\u0631\u0627\u0641\u064d \u0637\u0628\u064a.<\/p>\n
\u0645\u0639\u0644\u0648\u0645\u0627\u062a\u064c \u0631\u0626\u064a\u0633\u064a\u0629<\/p>\n
\u0622\u0644\u064a\u0629 \u0627\u0644\u0639\u0645\u0644<\/p>\n
\u064a\u0631\u062a\u0628\u0637 \u062a\u0627\u0631\u0627\u062a\u0627\u0645\u0627\u0628 \u0628\u0628\u0631\u0648\u062a\u064a\u0646 DLL3 \u0639\u0644\u0649 \u0633\u0637\u062d \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629 \u0648\u0645\u0633\u062a\u0642\u0628\u0644 CD3 \u0639\u0644\u0649 \u0633\u0637\u062d \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0641\u064a \u0627\u0644\u0648\u0642\u062a \u0646\u0641\u0633\u0647\u060c \u0645\u064f\u0634\u0643\u0650\u0651\u0644\u064b\u0627 “\u0645\u0634\u0628\u0643\u064b\u0627 \u0645\u0646\u0627\u0639\u064a\u064b\u0627” \u064a\u064f\u0648\u062c\u0650\u0651\u0647 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062a\u0627\u0626\u064a\u0629 \u0644\u0627\u0633\u062a\u0647\u062f\u0627\u0641 \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0648\u0631\u0645 \u0648\u0645\u0647\u0627\u062c\u0645\u062a\u0647\u0627.<\/p>\n
\u064a\u064f\u0639\u0628\u064e\u0651\u0631 \u0639\u0646 DLL3 \u0628\u0634\u0643\u0644\u064d \u0643\u0628\u064a\u0631\u064d \u0644\u062f\u0649 80%-85% \u0645\u0646 \u0645\u0631\u0636\u0649 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0631\u0626\u0629 \u0635\u063a\u064a\u0631 \u0627\u0644\u062e\u0644\u0627\u064a\u0627\u060c \u0648\u0644\u0643\u0646\u0647 \u0646\u0627\u062f\u0631\u064b\u0627 \u0645\u0627 \u064a\u0638\u0647\u0631 \u0641\u064a \u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u0637\u0628\u064a\u0639\u064a\u0629\u060c \u0644\u0630\u0627 \u064a\u062a\u0645\u064a\u0632 \u0627\u0644\u062f\u0648\u0627\u0621 \u0628\u062f\u0631\u062c\u0629\u064d \u0639\u0627\u0644\u064a\u0629\u064d \u0645\u0646 \u0627\u0644\u0627\u0633\u062a\u0647\u062f\u0627\u0641.
\n\u062f\u0648\u0627\u0639\u064a \u0627\u0644\u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0648\u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629<\/p>\n
\u0623\u0638\u0647\u0631\u062a \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0631\u0626\u0629 \u0635\u063a\u064a\u0631 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0646\u062a\u0643\u0633\/\u0627\u0644\u0645\u0642\u0627\u0648\u0645 \u0644\u0644\u0639\u0644\u0627\u062c (\u0645\u062b\u0644 \u062f\u0631\u0627\u0633\u0629 DeLLphi-301) \u0623\u0646 \u0645\u0639\u062f\u0644 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0645\u0648\u0636\u0648\u0639\u064a\u0629 (ORR) \u0644\u0644\u0645\u0631\u0636\u0649 \u0628\u0644\u063a \u062d\u0648\u0627\u0644\u064a 40%\u060c \u0648\u0628\u0644\u063a \u0645\u062a\u0648\u0633\u0637 \u200b\u200b\u0645\u062f\u0629 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 (DOR) 9.7 \u0623\u0634\u0647\u0631.<\/p>\n
\u062a\u062f\u0639\u0645 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u062d\u0627\u0644\u064a\u0629 \u0625\u0645\u0643\u0627\u0646\u064a\u0629 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647 \u0643\u0639\u0644\u0627\u062c \u0645\u0646 \u0627\u0644\u062e\u0637 \u0627\u0644\u062b\u0627\u0644\u062b \u0623\u0648 \u0627\u0644\u062e\u0637 \u0627\u0644\u0623\u062e\u064a\u0631.<\/p>\n
\u0627\u062d\u062a\u064a\u0627\u0637\u0627\u062a \u0627\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645<\/p>\n
\u064a\u062a\u0637\u0644\u0628 \u0645\u0631\u0627\u0642\u0628\u0629 \u0627\u0644\u0645\u0631\u064a\u0636 \u0641\u064a \u0627\u0644\u0645\u0633\u062a\u0634\u0641\u0649: \u0642\u062f \u062a\u062d\u062f\u062b \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0625\u0637\u0644\u0627\u0642 \u0627\u0644\u0633\u064a\u062a\u0648\u0643\u064a\u0646 (CRS) \u0628\u0639\u062f \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0623\u0648\u0644\u0649\u060c \u0648\u064a\u0644\u0632\u0645 \u0625\u062c\u0631\u0627\u0621 \u0645\u0631\u0627\u0642\u0628\u0629 \u062f\u0642\u064a\u0642\u0629 \u0644\u0645\u062f\u0629 48 \u0633\u0627\u0639\u0629 \u0639\u0644\u0649 \u0627\u0644\u0623\u0642\u0644.<\/p>\n
\u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u0622\u062b\u0627\u0631 \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629:<\/p>\n
\u062a\u0634\u0645\u0644 \u0627\u0644\u0622\u062b\u0627\u0631 \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629 \u0627\u0644\u0634\u0627\u0626\u0639\u0629 \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0625\u0637\u0644\u0627\u0642 \u0627\u0644\u0633\u064a\u062a\u0648\u0643\u064a\u0646 (CRS) (\u0627\u0644\u062d\u0645\u0649\u060c \u0648\u0627\u0646\u062e\u0641\u0627\u0636 \u0636\u063a\u0637 \u0627\u0644\u062f\u0645)\u060c \u0648\u0627\u0644\u062a\u0639\u0628\u060c \u0648\u0641\u0642\u062f\u0627\u0646 \u0627\u0644\u0634\u0647\u064a\u0629\u060c \u0648\u063a\u064a\u0631\u0647\u0627.<\/p>\n
\u062a\u062a\u0637\u0644\u0628 \u0627\u0644\u0622\u062b\u0627\u0631 \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629 \u0627\u0644\u0634\u062f\u064a\u062f\u0629 \u062a\u062f\u062e\u0644\u0627\u064b \u0641\u064a \u0627\u0644\u0648\u0642\u062a \u0627\u0644\u0645\u0646\u0627\u0633\u0628\u060c \u0645\u062b\u0644 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062a\u0648\u0633\u064a\u0644\u064a\u0632\u0648\u0645\u0627\u0628 \u0644\u0644\u0633\u064a\u0637\u0631\u0629 \u0639\u0644\u0649 \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0625\u0637\u0644\u0627\u0642 \u0627\u0644\u0633\u064a\u062a\u0648\u0643\u064a\u0646.
\n\u0627\u0644\u062a\u0642\u062f\u0645 \u0627\u0644\u0633\u0631\u064a\u0631\u064a \u0648\u0627\u0644\u0642\u064a\u0648\u062f<\/p>\n
\u0641\u064a \u0639\u0627\u0645 \u0662\u0660\u0662\u0664\u060c \u0645\u0646\u062d\u062a\u0647 \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 (FDA) “\u062a\u0623\u0647\u064a\u0644 \u0645\u0631\u0627\u062c\u0639\u0629 \u0627\u0644\u0623\u0648\u0644\u0648\u064a\u0629”\u060c \u0648\u0645\u0646 \u0627\u0644\u0645\u062a\u0648\u0642\u0639 \u0623\u0646 \u062a\u062a\u0645 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u064a\u0647 \u0628\u0634\u0643\u0644 \u0623\u0633\u0631\u0639 \u0641\u064a \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644.<\/p>\n
\u064a\u062d\u062a\u0627\u062c \u0627\u0644\u0645\u0631\u0636\u0649 \u0625\u0644\u0649 \u0641\u062d\u0635 \u0644\u0644\u0643\u0634\u0641 \u0639\u0646 \u062a\u0639\u0628\u064a\u0631 DLL3\u060c \u0648\u0644\u0627 \u062a\u0632\u0627\u0644 \u0641\u0639\u0627\u0644\u064a\u062a\u0647 \u0648\u0633\u0644\u0627\u0645\u062a\u0647 \u0639\u0644\u0649 \u0627\u0644\u0645\u062f\u0649 \u0627\u0644\u0637\u0648\u064a\u0644 \u0628\u062d\u0627\u062c\u0629 \u0625\u0644\u0649 \u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a.<\/p>\n
\u0627\u0644\u0625\u0631\u0634\u0627\u062f\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0629
\n\u064a\u064f\u0635\u0631\u0641 \u062a\u0627\u0631\u0627\u062a\u0648\u0645\u0648\u0645\u0627\u0628 \u0628\u0648\u0635\u0641\u0629 \u0637\u0628\u064a\u0629\u060c \u0648\u064a\u062c\u0628 \u0639\u0644\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647 \u0628\u0639\u062f \u062a\u0642\u064a\u064a\u0645 \u0645\u0646 \u0637\u0628\u064a\u0628 \u0623\u0648\u0631\u0627\u0645\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643:<\/p>\n
\u0627\u0644\u062a\u0623\u0643\u062f \u0645\u0646 \u062d\u0627\u0644\u0629 \u062a\u0639\u0628\u064a\u0631 DLL3 \u0641\u064a \u0627\u0644\u0648\u0631\u0645.<\/p>\n
\u062a\u0642\u064a\u064a\u0645 \u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646 \u062a\u0627\u0631\u064a\u062e \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0633\u0627\u0628\u0642 \u0648\u0627\u0644\u062d\u0627\u0644\u0629 \u0627\u0644\u0628\u062f\u0646\u064a\u0629 \u0645\u0646\u0627\u0633\u0628\u064a\u0646 \u0644\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0646\u0627\u0639\u064a.<\/p>\n
\u0623\u062b\u0646\u0627\u0621 \u0627\u0644\u0639\u0644\u0627\u062c\u060c \u064a\u062c\u0628 \u0645\u0631\u0627\u0642\u0628\u0629 \u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u062f\u0645\u060c \u0648\u0648\u0638\u0627\u0626\u0641 \u0627\u0644\u0643\u0628\u062f \u0648\u0627\u0644\u0643\u0644\u0649\u060c \u0648\u0627\u0644\u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0627\u0644\u0636\u0627\u0631\u0629 \u0627\u0644\u0645\u062a\u0639\u0644\u0642\u0629 \u0628\u0627\u0644\u0645\u0646\u0627\u0639\u0629 \u0628\u0627\u0646\u062a\u0638\u0627\u0645.<\/p>\n
\u062d\u0627\u0644\u064a\u064b\u0627\u060c \u0644\u0645 \u064a\u062f\u062e\u0644 \u0647\u0630\u0627 \u0627\u0644\u062f\u0648\u0627\u0621 \u0641\u064a \u0627\u0644\u0645\u0645\u0627\u0631\u0633\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u0631\u0648\u062a\u064a\u0646\u064a\u0629. \u064a\u0645\u0643\u0646 \u0644\u0644\u0645\u0631\u0636\u0649 \u0645\u062a\u0627\u0628\u0639\u0629 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 (\u0645\u062b\u0644 NCT05060016) \u0648\u0627\u0644\u062a\u0642\u062f\u0645 \u0628\u0637\u0644\u0628 \u0644\u0644\u0645\u0634\u0627\u0631\u0643\u0629. \u064a\u062c\u0628 \u0623\u0646 \u064a\u0643\u0648\u0646 \u0623\u064a \u0642\u0631\u0627\u0631 \u0628\u0634\u0623\u0646 \u0627\u0644\u062f\u0648\u0627\u0621 \u0645\u062a\u0648\u0627\u0641\u0642\u064b\u0627 \u0645\u0639 \u0627\u0644\u062d\u0627\u0644\u0629 \u0627\u0644\u0641\u0631\u062f\u064a\u0629\u060c \u0645\u0639 \u0627\u062a\u0628\u0627\u0639 \u0646\u0635\u064a\u062d\u0629 \u0627\u0644\u0637\u0628\u064a\u0628 \u0628\u062f\u0642\u0629.<\/p>\n
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