\u062f\u0648\u0627\u0639\u064a \u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u062a\u0631\u0648\u0643\u0627\u0628 (\u0643\u0627\u0628\u064a\u0641\u0627\u0633\u064a\u0631\u062a\u064a\u0628)
\n\u062a\u0631\u0648\u0643\u0627\u0628 \u0647\u0648 \u0645\u062b\u0628\u0637 \u0643\u064a\u0646\u0627\u0632\u060c \u064a\u064f\u0633\u062a\u0639\u0645\u0644 \u0645\u0639 \u0627\u0644\u0641\u0648\u0644\u0641\u064a\u0633\u062a\u0631\u0627\u0646\u062a \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0628\u0627\u0644\u063a\u064a\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0627\u0644\u0645\u062a\u0642\u062f\u0645 \u0645\u0648\u0636\u0639\u064a\u064b\u0627 \u0623\u0648 \u0627\u0644\u0646\u0642\u064a\u0644\u064a\u060c \u0633\u0648\u0627\u0621\u064b \u0643\u0627\u0646 \u0625\u064a\u062c\u0627\u0628\u064a\u064b\u0627 \u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u0627\u062a\u060c \u0623\u0648 \u0633\u0644\u0628\u064a\u064b\u0627 \u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0639\u0627\u0645\u0644 \u0627\u0644\u0646\u0645\u0648 \u0627\u0644\u0628\u0634\u0631\u064a 2 (HER2)\u060c \u0648\u0627\u0644\u0630\u064a\u0646 \u0644\u062f\u064a\u0647\u0645 \u0637\u0641\u0631\u0629 \u0648\u0627\u062d\u062f\u0629 \u0623\u0648 \u0623\u0643\u062b\u0631 \u0641\u064a \u062c\u064a\u0646\u0627\u062a PIK3CA\/AKT1\/PTEN\u060c \u0643\u0645\u0627 \u0647\u0648 \u0645\u064f\u0643\u062a\u0634\u0641 \u0628\u0648\u0627\u0633\u0637\u0629 \u0627\u062e\u062a\u0628\u0627\u0631 \u0645\u0639\u062a\u0645\u062f \u0645\u0646 \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629\u060c \u0648\u0627\u0644\u0630\u064a\u0646 \u062a\u0637\u0648\u0631\u062a \u062d\u0627\u0644\u062a\u0647\u0645 \u0628\u0639\u062f \u0646\u0638\u0627\u0645 \u0639\u0644\u0627\u062c\u064a \u0648\u0627\u062d\u062f \u0639\u0644\u0649 \u0627\u0644\u0623\u0642\u0644 \u0642\u0627\u0626\u0645 \u0639\u0644\u0649 \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0641\u064a \u062d\u0627\u0644\u0629 \u0627\u0644\u0645\u0631\u0636 \u0627\u0644\u0646\u0642\u064a\u0644\u064a\u060c \u0623\u0648 \u0627\u0644\u0630\u064a\u0646 \u0627\u0646\u062a\u0643\u0633\u0648\u0627 \u062e\u0644\u0627\u0644 12 \u0634\u0647\u0631\u064b\u0627 \u0628\u0639\u062f \u0625\u0643\u0645\u0627\u0644 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0633\u0627\u0639\u062f.<\/p>\n
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\n160 \u0645\u0644\u063a \u0648200 \u0645\u0644\u063a<\/p>\n
\u062c\u0631\u0639\u0629 \u062a\u0631\u0648\u0643\u0627\u0628 (\u0643\u0627\u0628\u064a\u0641\u0627\u0633\u064a\u0631\u062a\u064a\u0628)
\n\u2022 \u064a\u064f\u062e\u062a\u0627\u0631 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u0635\u0627\u0628\u0648\u0646 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0627\u0644\u0645\u062a\u0642\u062f\u0645 \u0623\u0648 \u0627\u0644\u0646\u0642\u064a\u0644\u064a\u060c \u0633\u0648\u0627\u0621\u064b \u0643\u0627\u0646 \u0625\u064a\u062c\u0627\u0628\u064a\u064b\u0627 \u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0623\u0648 \u0633\u0644\u0628\u064a\u064b\u0627 \u0644\u0640 HER2\u060c \u0644\u0644\u0639\u0644\u0627\u062c \u0628\u062a\u0631\u0648\u0643\u0627\u0628 \u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u0648\u062c\u0648\u062f \u0648\u0627\u062d\u062f \u0623\u0648 \u0623\u0643\u062b\u0631 \u0645\u0646 \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0627\u0644\u062a\u0627\u0644\u064a\u0629 \u0641\u064a \u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u0648\u0631\u0645: PIK3CA\/AKT1\/PTEN.<\/p>\n
\u2022 \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u0648\u0635\u0649 \u0628\u0647\u0627: 400 \u0645\u0644\u063a \u0641\u0645\u0648\u064a\u064b\u0627 \u0645\u0631\u062a\u064a\u0646 \u064a\u0648\u0645\u064a\u064b\u0627\u060c \u0645\u0639 \u0623\u0648 \u0628\u062f\u0648\u0646 \u0637\u0639\u0627\u0645\u060c \u0644\u0645\u062f\u0629 4 \u0623\u064a\u0627\u0645 \u0645\u062a\u062a\u0627\u0644\u064a\u0629\u060c \u062a\u0644\u064a\u0647\u0627 3 \u0623\u064a\u0627\u0645 \u0631\u0627\u062d\u0629.<\/p>\n
\u0645\u0648\u0627\u0646\u0639 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062a\u0631\u0648\u0643\u0627\u0628 (\u0643\u0627\u0628\u064a\u0641\u0627\u0633\u064a\u0631\u062a\u064a\u0628):
\n\u0641\u0631\u0637 \u0627\u0644\u062d\u0633\u0627\u0633\u064a\u0629 \u0627\u0644\u0634\u062f\u064a\u062f \u0644\u062a\u0631\u0648\u0643\u0627\u0628 \u0623\u0648 \u0623\u064a \u0645\u0646 \u0645\u0643\u0648\u0646\u0627\u062a\u0647.<\/p>\n
\u0627\u0644\u062a\u0641\u0627\u0639\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0644\u062a\u0631\u0648\u0643\u0627\u0628 (\u0643\u0627\u0628\u064a\u0641\u0627\u0633\u064a\u0631\u062a\u064a\u0628):
\n\u2022 \u0645\u062b\u0628\u0637\u0627\u062a CYP3A \u0627\u0644\u0642\u0648\u064a\u0629: \u062a\u062c\u0646\u0628 \u0627\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u062a\u0632\u0627\u0645\u0646. \u0625\u0630\u0627 \u0644\u0645 \u064a\u0643\u0646 \u0645\u0646 \u0627\u0644\u0645\u0645\u0643\u0646 \u062a\u062c\u0646\u0628 \u0627\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u062a\u0632\u0627\u0645\u0646\u060c \u062e\u0641\u0651\u0636 \u062c\u0631\u0639\u0629 \u062a\u0631\u0648\u0643\u0627\u0628. \u2022 \u0645\u062b\u0628\u0637\u0627\u062a CYP3A \u0645\u062a\u0648\u0633\u0637\u0629 \u0627\u0644\u062a\u0623\u062b\u064a\u0631: \u062e\u0641\u0651\u0636 \u062c\u0631\u0639\u0629 TRUQAP.<\/p>\n
\u0645\u062d\u0641\u0632\u0627\u062a CYP3A \u0627\u0644\u0642\u0648\u064a\u0629 \u0648\u0627\u0644\u0645\u062a\u0648\u0633\u0637\u0629: \u062a\u062c\u0646\u0651\u0628 \u0627\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0645\u062a\u0632\u0627\u0645\u0646.<\/p>\n
\u0627\u0633\u062a\u062e\u062f\u0627\u0645 Truqap (\u0643\u0627\u0628\u064a\u0641\u0627\u0633\u064a\u0631\u062a\u064a\u0628) \u0641\u064a \u0641\u0626\u0627\u062a \u0633\u0643\u0627\u0646\u064a\u0629 \u0645\u062d\u062f\u062f\u0629.<\/p>\n
\u0627\u0644\u0631\u0636\u0627\u0639\u0629: \u0644\u0627 \u064a\u064f\u0646\u0635\u062d \u0628\u0627\u0644\u0631\u0636\u0627\u0639\u0629 \u0627\u0644\u0637\u0628\u064a\u0639\u064a\u0629.<\/p>\n
\u0622\u0644\u064a\u0629 \u0639\u0645\u0644 Truqap (\u0643\u0627\u0628\u064a\u0641\u0627\u0633\u064a\u0631\u062a\u064a\u0628):<\/p>\n
\u0643\u0627\u0628\u064a\u0641\u0627\u0633\u064a\u0631\u062a\u064a\u0628 \u0645\u062b\u0628\u0637 \u0644\u062c\u0645\u064a\u0639 \u0627\u0644\u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u062b\u0644\u0627\u062b\u0629 \u0627\u0644\u0645\u062a\u0645\u0627\u062b\u0644\u0629 \u0645\u0646 \u0643\u064a\u0646\u0627\u0632 \u0633\u064a\u0631\u064a\u0646\/\u062b\u0631\u064a\u0648\u0646\u064a\u0646 AKT (AKT1\u060c AKT2\u060c \u0648AKT3)\u060c \u0648\u064a\u0645\u0646\u0639 \u0641\u0633\u0641\u0631\u0629 \u0631\u0643\u0627\u0626\u0632 AKT \u0627\u0644\u0644\u0627\u062d\u0642\u0629. \u064a\u062a\u0645 \u062a\u0646\u0634\u064a\u0637 AKT \u0641\u064a \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0639\u0646 \u0637\u0631\u064a\u0642 \u062a\u0646\u0634\u064a\u0637 \u0645\u0633\u0627\u0631\u0627\u062a \u0627\u0644\u0625\u0634\u0627\u0631\u0627\u062a \u0627\u0644\u0633\u0627\u0628\u0642\u0629\u060c \u0648\u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0641\u064a AKT1\u060c \u0648\u0641\u0642\u062f\u0627\u0646 \u0648\u0638\u064a\u0641\u0629 \u0645\u062a\u0645\u0627\u062b\u0644 \u0627\u0644\u0641\u0648\u0633\u0641\u0627\u062a\u064a\u0632 \u0648\u0627\u0644\u062a\u0646\u0633\u064a\u0646 (PTEN)\u060c \u0648\u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0641\u064a \u0627\u0644\u0648\u062d\u062f\u0629 \u0627\u0644\u0641\u0631\u0639\u064a\u0629 \u0627\u0644\u0645\u062d\u0641\u0632\u0629 \u0623\u0644\u0641\u0627 \u0645\u0646 \u0641\u0648\u0633\u0641\u0627\u062a\u064a\u062f\u064a\u0644\u064a\u0646\u0648\u0633\u064a\u062a\u0648\u0644 3-\u0643\u064a\u0646\u0627\u0632 (PIK3CA). \u0641\u064a \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0645\u062e\u0628\u0631\u064a\u0629\u060c \u062e\u0641\u0651\u0636 \u0643\u0627\u0628\u064a\u0641\u0627\u0633\u064a\u0631\u062a\u064a\u0628 \u0646\u0645\u0648 \u0633\u0644\u0627\u0644\u0627\u062a \u062e\u0644\u0627\u064a\u0627 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u062a\u0644\u0643 \u0627\u0644\u062a\u064a \u062a\u062d\u0645\u0644 \u0637\u0641\u0631\u0627\u062a \u0630\u0627\u062a \u0635\u0644\u0629 \u0641\u064a \u062c\u064a\u0646 PIK3CA \u0623\u0648 AKT1 \u0623\u0648 \u062a\u063a\u064a\u0631\u0627\u062a \u0641\u064a \u062c\u064a\u0646 PTEN. \u0641\u064a \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0645\u062e\u0628\u0631\u064a\u0629\u060c \u062b\u0628\u0651\u0637 \u0643\u0627\u0628\u064a\u0641\u0627\u0633\u064a\u0631\u062a\u064a\u0628\u060c \u0628\u0645\u0641\u0631\u062f\u0647 \u0648\u0628\u0627\u0644\u0627\u0634\u062a\u0631\u0627\u0643 \u0645\u0639 \u0627\u0644\u0641\u0648\u0644\u0641\u064a\u0633\u062a\u0631\u0627\u0646\u062a\u060c \u0646\u0645\u0648 \u0627\u0644\u0648\u0631\u0645 \u0641\u064a \u0646\u0645\u0627\u0630\u062c \u0632\u0631\u0627\u0639\u0629 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0623\u062c\u0646\u0628\u064a\u0629 \u0644\u0644\u0641\u0626\u0631\u0627\u0646 \u0627\u0644\u0645\u0648\u062c\u0628\u0629 \u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646 \u0645\u0646 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u060c \u0645\u0639 \u062a\u063a\u064a\u0631\u0627\u062a \u0641\u064a \u062c\u064a\u0646\u0627\u062a PIK3CA \u0648AKT1 \u0648PTEN.<\/p>\n
\u062a\u062e\u0632\u064a\u0646 \u062a\u0631\u0648\u0643\u0627\u0628 (\u0643\u0627\u0628\u064a\u0641\u0627\u0633\u064a\u0631\u062a\u064a\u0628)<\/p>\n
\u064a\u064f\u062d\u0641\u0638 \u062a\u0631\u0648\u0643\u0627\u0628 \u0641\u064a \u0639\u0628\u0648\u062a\u0647 \u0627\u0644\u0623\u0635\u0644\u064a\u0629 \u0639\u0646\u062f \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 \u062a\u062a\u0631\u0627\u0648\u062d \u0628\u064a\u0646 20 \u064825 \u062f\u0631\u062c\u0629 \u0645\u0626\u0648\u064a\u0629 (\u0645\u0646 68 \u0625\u0644\u0649 77 \u062f\u0631\u062c\u0629 \u0641\u0647\u0631\u0646\u0647\u0627\u064a\u062a). \u064a\u064f\u0633\u0645\u062d \u0628\u062a\u063a\u064a\u0631\u0627\u062a \u062f\u0631\u062c\u0629 \u0627\u0644\u062d\u0631\u0627\u0631\u0629 \u0628\u064a\u0646 15 \u064830 \u062f\u0631\u062c\u0629 \u0645\u0626\u0648\u064a\u0629 (\u0645\u0646 59 \u0625\u0644\u0649 86 \u062f\u0631\u062c\u0629 \u0641\u0647\u0631\u0646\u0647\u0627\u064a\u062a).<\/p>\n
\u0627\u062d\u062a\u064a\u0627\u0637\u0627\u062a \u062a\u0631\u0648\u0643\u0627\u0628 (\u0643\u0627\u0628\u064a\u0641\u0627\u0633\u064a\u0631\u062a\u064a\u0628)<\/p>\n
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