\u062f\u0648\u0627\u0639\u064a \u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0623\u0648\u0631\u0633\u064a\u0631\u062f\u0648 (\u0625\u064a\u0644\u0627\u0633\u062a\u0631\u0627\u0646\u062a)
\n\u064a\u064f\u0633\u062a\u0639\u0645\u0644 \u0623\u0648\u0631\u0633\u064a\u0631\u062f\u0648 \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0646\u0633\u0627\u0621 \u0628\u0639\u062f \u0627\u0646\u0642\u0637\u0627\u0639 \u0627\u0644\u0637\u0645\u062b \u0623\u0648 \u0627\u0644\u0631\u062c\u0627\u0644 \u0627\u0644\u0628\u0627\u0644\u063a\u064a\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0627\u0644\u0645\u062a\u0642\u062f\u0645 \u0623\u0648 \u0627\u0644\u0646\u0642\u064a\u0644\u064a\u060c \u0627\u0644\u0645\u0648\u062c\u0628 \u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646 (ER)\u060c \u0648\u0627\u0644\u0633\u0627\u0644\u0628 \u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0639\u0627\u0645\u0644 \u0646\u0645\u0648 \u0627\u0644\u0628\u0634\u0631\u0629 \u0627\u0644\u0628\u0634\u0631\u064a 2 (HER2)\u060c \u0648\u0627\u0644\u0645\u062a\u062d\u0648\u0631 \u0641\u064a ESR1\u060c \u0648\u0627\u0644\u0630\u064a\u0646 \u062a\u0637\u0648\u0631\u062a \u062d\u0627\u0644\u062a\u0647\u0645 \u0628\u0639\u062f \u0639\u0644\u0627\u062c \u0647\u0631\u0645\u0648\u0646\u064a \u0648\u0627\u062d\u062f \u0639\u0644\u0649 \u0627\u0644\u0623\u0642\u0644.<\/p>\n
\u0645\u0648\u0627\u0635\u0641\u0627\u062a \u0623\u0648\u0631\u0633\u064a\u0631\u062f\u0648 (\u0625\u064a\u0644\u0627\u0633\u062a\u0631\u0627\u0646\u062a)
\n\u0627\u0644\u0623\u0642\u0631\u0627\u0635: 345 \u0645\u0644\u063a \u064886 \u0645\u0644\u063a<\/p>\n
\u062c\u0631\u0639\u0629 \u0623\u0648\u0631\u0633\u064a\u0631\u062f\u0648 (\u0625\u064a\u0644\u0627\u0633\u062a\u0631\u0627\u0646\u062a) \u0648\u0637\u0631\u064a\u0642\u0629 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647
\n\u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0645\u0648\u0635\u0649 \u0628\u0647\u0627 \u0645\u0646 \u0623\u0648\u0631\u0633\u064a\u0631\u062f\u0648 \u0647\u064a 345 \u0645\u0644\u063a\u060c \u062a\u0624\u062e\u0630 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0641\u0645 \u0645\u0631\u0629 \u0648\u0627\u062d\u062f\u0629 \u064a\u0648\u0645\u064a\u064b\u0627 \u0645\u0639 \u0627\u0644\u0637\u0639\u0627\u0645 \u062d\u062a\u0649 \u064a\u062a\u0637\u0648\u0631 \u0627\u0644\u0645\u0631\u0636 \u0623\u0648 \u062a\u062d\u062f\u062b \u0633\u0645\u064a\u0629 \u063a\u064a\u0631 \u0645\u0642\u0628\u0648\u0644\u0629.
\n\u062a\u0646\u0627\u0648\u0644 \u0623\u0648\u0631\u0633\u064a\u0631\u062f\u0648 \u0641\u064a \u0646\u0641\u0633 \u0627\u0644\u0648\u0642\u062a \u062a\u0642\u0631\u064a\u0628\u064b\u0627 \u0643\u0644 \u064a\u0648\u0645 \u0645\u0639 \u0627\u0644\u0637\u0639\u0627\u0645 \u0644\u062a\u0642\u0644\u064a\u0644 \u0627\u0644\u063a\u062b\u064a\u0627\u0646 \u0648\u0627\u0644\u0642\u064a\u0621.
\n\u0627\u0628\u062a\u0644\u0639 \u0623\u0642\u0631\u0627\u0635 \u0623\u0648\u0631\u0633\u064a\u0631\u062f\u0648 \u0643\u0627\u0645\u0644\u0629\u060c \u0648\u0644\u0627 \u062a\u0645\u0636\u063a\u0647\u0627 \u0623\u0648 \u062a\u0633\u062d\u0642\u0647\u0627 \u0623\u0648 \u062a\u0634\u0642\u0647\u0627 \u0642\u0628\u0644 \u0628\u0644\u0639\u0647\u0627. \u0644\u0627 \u062a\u062a\u0646\u0627\u0648\u0644 \u0623\u064a \u0623\u0642\u0631\u0627\u0635 \u0623\u0648\u0631\u0633\u064a\u0631\u062f\u0648 \u0645\u0643\u0633\u0648\u0631\u0629 \u0623\u0648 \u0645\u062a\u0634\u0642\u0642\u0629 \u0623\u0648 \u062a\u0628\u062f\u0648 \u0645\u0643\u0633\u0648\u0631\u0629.
\n\u0641\u064a \u062d\u0627\u0644 \u0646\u0633\u064a\u0627\u0646 \u062a\u0646\u0627\u0648\u0644 \u062c\u0631\u0639\u0629 \u0644\u0623\u0643\u062b\u0631 \u0645\u0646 6 \u0633\u0627\u0639\u0627\u062a \u0623\u0648 \u062d\u062f\u0648\u062b \u0642\u064a\u0621\u060c \u064a\u064f\u0631\u062c\u0649 \u062a\u062e\u0637\u064a \u062a\u0644\u0643 \u0627\u0644\u062c\u0631\u0639\u0629 \u0648\u062a\u0646\u0627\u0648\u0644 \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u062a\u0627\u0644\u064a\u0629 \u0641\u064a \u0645\u0648\u0639\u062f\u0647\u0627 \u0627\u0644\u0645\u0639\u062a\u0627\u062f \u0641\u064a \u0627\u0644\u064a\u0648\u0645 \u0627\u0644\u062a\u0627\u0644\u064a.<\/p>\n
\u0645\u0648\u0627\u0646\u0639 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0623\u0648\u0631\u0633\u064a\u0631\u062f\u0648 (\u0625\u064a\u0644\u0627\u0633\u064a\u0633\u062a\u0631\u0627\u0646\u062a)
\n\u0644\u0627 \u064a\u0648\u062c\u062f<\/p>\n
\u0622\u0644\u064a\u0629 \u0639\u0645\u0644 \u0623\u0648\u0631\u0633\u064a\u0631\u062f\u0648 (\u0625\u064a\u0644\u0627\u0633\u064a\u0633\u062a\u0631\u0627\u0646\u062a)<\/p>\n
\u0625\u064a\u0644\u0627\u0633\u064a\u0633\u062a\u0631\u0627\u0646\u062a \u0647\u0648 \u0645\u0636\u0627\u062f \u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646\u060c \u064a\u0631\u062a\u0628\u0637 \u0628\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646 \u0623\u0644\u0641\u0627 (ER\u03b1). \u0641\u064a \u062e\u0644\u0627\u064a\u0627 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0627\u0644\u0645\u0648\u062c\u0628\u0629 \u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646 (ER+) \u0648\u0627\u0644\u0633\u0644\u0628\u064a\u0629 \u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a HER2 (HER2-)\u060c \u064a\u062b\u0628\u0637 \u0625\u064a\u0644\u0627\u0633\u064a\u0633\u062a\u0631\u0627\u0646\u062a \u062a\u0643\u0627\u062b\u0631 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0628\u0648\u0633\u0627\u0637\u0629 17\u03b2-\u0625\u0633\u062a\u0631\u0627\u062f\u064a\u0648\u0644\u060c \u0648\u064a\u062d\u0641\u0632 \u062a\u0631\u0643\u064a\u0632\u0647 \u062a\u062d\u0644\u0644 \u0628\u0631\u0648\u062a\u064a\u0646 ER\u03b1 \u0628\u0648\u0633\u0627\u0637\u0629 \u0645\u0633\u0627\u0631 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0627\u0632\u0648\u0645. \u0623\u0638\u0647\u0631 \u0625\u064a\u0644\u0627\u0633\u064a\u0633\u062a\u0631\u0627\u0646\u062a \u0646\u0634\u0627\u0637\u064b\u0627 \u0645\u0636\u0627\u062f\u064b\u0627 \u0644\u0644\u0623\u0648\u0631\u0627\u0645 \u0641\u064a \u0627\u0644\u0645\u062e\u062a\u0628\u0631 \u0648\u0641\u064a \u0627\u0644\u062c\u0633\u0645 \u0627\u0644\u062d\u064a\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0646\u0645\u0627\u0630\u062c \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0627\u0644\u0645\u0648\u062c\u0628\u0629 \u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646 (ER+) \u0648\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a HER2- \u0627\u0644\u0645\u0642\u0627\u0648\u0645\u0629 \u0644\u0645\u062b\u0628\u0637\u0627\u062a \u0641\u0648\u0644\u0641\u064a\u0633\u062a\u0631\u0627\u0646\u062a \u0648\u0645\u062b\u0628\u0637\u0627\u062a \u0627\u0644\u0643\u064a\u0646\u0627\u0632 4\/6 \u0627\u0644\u0645\u0639\u062a\u0645\u062f\u0629 \u0639\u0644\u0649 \u0627\u0644\u0633\u064a\u0643\u0644\u064a\u0646\u060c \u0648\u0646\u0645\u0627\u0630\u062c \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0627\u0644\u062a\u064a \u062a\u062d\u062a\u0648\u064a \u0639\u0644\u0649 \u0637\u0641\u0631\u0627\u062a \u0641\u064a \u062c\u064a\u0646 \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u0625\u0633\u062a\u0631\u0648\u062c\u064a\u0646 1 (ESR1).<\/p>\n
\u0623\u0648\u0631\u0633\u064a\u0631\u062f\u0648 (\u0625\u064a\u0644\u0627\u0633\u062a\u0631\u0627\u0646\u062a) \u0627\u0644\u062a\u062e\u0632\u064a\u0646
\n\u064a\u064f\u062d\u0641\u0638 \u0641\u064a \u062f\u0631\u062c\u0629 \u062d\u0631\u0627\u0631\u0629 \u062a\u062a\u0631\u0627\u0648\u062d \u0628\u064a\u0646 \u0662\u0660 \u0648\u0662\u0665 \u062f\u0631\u062c\u0629 \u0645\u0626\u0648\u064a\u0629\u060c \u0645\u0639 \u0627\u0644\u0633\u0645\u0627\u062d \u0628\u062a\u063a\u064a\u0631\u0627\u062a \u0637\u0641\u064a\u0641\u0629 \u0628\u064a\u0646 \u0661\u0665 \u0648\u0663\u0660 \u062f\u0631\u062c\u0629 \u0645\u0626\u0648\u064a\u0629.<\/p>\n
\u0627\u062d\u062a\u064a\u0627\u0637\u0627\u062a \u0623\u0648\u0631\u0633\u064a\u0631\u062f\u0648 (\u0625\u064a\u0644\u0627\u0633\u062a\u0631\u0627\u0646\u062a)
\n\u0661. \u0627\u0636\u0637\u0631\u0627\u0628 \u0634\u062d\u0645\u064a\u0627\u062a \u0627\u0644\u062f\u0645
\n\u0628\u0644\u063a\u062a \u0646\u0633\u0628\u0629 \u062d\u062f\u0648\u062b \u0627\u0631\u062a\u0641\u0627\u0639 \u0643\u0648\u0644\u064a\u0633\u062a\u0631\u0648\u0644 \u0627\u0644\u062f\u0645 \u0648\u0627\u0631\u062a\u0641\u0627\u0639 \u0634\u062d\u0648\u0645 \u0627\u0644\u062f\u0645 \u0627\u0644\u062b\u0644\u0627\u062b\u064a\u0629 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u062a\u0646\u0627\u0648\u0644\u0648\u0646 \u0623\u0648\u0631\u0633\u064a\u0631\u062f\u0648 \u0663\u0660\u066a \u0648\u0662\u0667\u066a \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a. \u0648\u0628\u0644\u063a\u062a \u0646\u0633\u0628\u0629 \u062d\u062f\u0648\u062b \u0627\u0631\u062a\u0641\u0627\u0639 \u0643\u0648\u0644\u064a\u0633\u062a\u0631\u0648\u0644 \u0627\u0644\u062f\u0645 \u0648\u0627\u0631\u062a\u0641\u0627\u0639 \u0634\u062d\u0648\u0645 \u0627\u0644\u062f\u0645 \u0627\u0644\u062b\u0644\u0627\u062b\u064a\u0629 \u0645\u0646 \u0627\u0644\u062f\u0631\u062c\u062a\u064a\u0646 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 \u0648\u0627\u0644\u0631\u0627\u0628\u0639\u0629 \u0660.\u0669\u066a \u0648\u0662.\u0662\u066a \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a. \u064a\u062c\u0628 \u0645\u0631\u0627\u0642\u0628\u0629 \u0646\u0633\u0628\u0629 \u0627\u0644\u062f\u0647\u0648\u0646 \u0641\u064a \u0627\u0644\u062f\u0645 \u0642\u0628\u0644 \u0627\u0644\u0628\u062f\u0621 \u0628\u0627\u0644\u0639\u0644\u0627\u062c\u060c \u0648\u0628\u0634\u0643\u0644 \u0645\u0646\u062a\u0638\u0645 \u0623\u062b\u0646\u0627\u0621 \u062a\u0646\u0627\u0648\u0644 \u0623\u0648\u0631\u0633\u064a\u0631\u062f\u0648.<\/p>\n
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