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\u0622\u0644\u064a\u0629 \u0627\u0644\u0639\u0645\u0644<\/p>\n

\u062a\u062b\u0628\u064a\u0637 \u0625\u0646\u0632\u064a\u0645 PDE4: \u064a\u064f\u0642\u0644\u0644 \u0645\u0646 \u0625\u0637\u0644\u0627\u0642 \u0648\u0633\u0637\u0627\u0621 \u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628 (\u0645\u062b\u0644 TNF-\u03b1 \u0648IL-8)\u060c \u0645\u0645\u0627 \u064a\u064f\u062e\u0641\u0641 \u0645\u0646 \u0627\u0644\u062a\u0647\u0627\u0628 \u0645\u062c\u0631\u0649 \u0627\u0644\u0647\u0648\u0627\u0621.<\/p>\n

\u064a\u064f\u062d\u0633\u0651\u0646 \u0648\u0638\u0627\u0626\u0641 \u0627\u0644\u0631\u0626\u0629: \u064a\u064f\u0645\u0643\u0646 \u0623\u0646 \u064a\u064f\u0642\u0644\u0644 \u0627\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0637\u0648\u064a\u0644 \u0627\u0644\u0623\u0645\u062f \u0645\u0646 \u062a\u0643\u0631\u0627\u0631 \u0646\u0648\u0628\u0627\u062a \u0645\u0631\u0636 \u0627\u0644\u0627\u0646\u0633\u062f\u0627\u062f \u0627\u0644\u0631\u0626\u0648\u064a \u0627\u0644\u0645\u0632\u0645\u0646 \u0648\u064a\u064f\u0628\u0637\u0626 \u062a\u0637\u0648\u0631 \u0627\u0644\u0645\u0631\u0636.<\/p>\n

\u062f\u0648\u0627\u0639\u064a \u0627\u0644\u0627\u0633\u062a\u0639\u0645\u0627\u0644<\/p>\n

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\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0633\u0627\u0639\u062f: \u064a\u064f\u0633\u062a\u062e\u062f\u0645 \u0639\u0627\u062f\u0629\u064b \u0645\u0639 \u0645\u0648\u0633\u0639\u0627\u062a \u0642\u0635\u0628\u064a\u0629 \u0623\u062e\u0631\u0649 (\u0645\u062b\u0644 \u0646\u0627\u0647\u0636\u0627\u062a \u0628\u064a\u062a\u0627 2 \u0637\u0648\u064a\u0644\u0629 \u0627\u0644\u0645\u0641\u0639\u0648\u0644).<\/p>\n

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\u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0627\u0644\u0646\u0641\u0633\u064a\u0629: \u0646\u0627\u062f\u0631\u064b\u0627 \u0645\u0627 \u064a\u064f\u0635\u0627\u0628 \u0627\u0644\u0645\u0631\u064a\u0636 \u0628\u0627\u0644\u0623\u0631\u0642 \u0648\u0627\u0644\u0642\u0644\u0642\u061b \u062a\u062a\u0637\u0644\u0628 \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0627\u0644\u0634\u062f\u064a\u062f\u0629 \u0627\u0644\u062a\u0648\u0642\u0641 \u0639\u0646 \u062a\u0646\u0627\u0648\u0644 \u0627\u0644\u062f\u0648\u0627\u0621.<\/p>\n

\u0627\u0644\u0627\u062d\u062a\u064a\u0627\u0637\u0627\u062a
\n\u0645\u0648\u0627\u0646\u0639 \u0627\u0644\u0627\u0633\u062a\u0639\u0645\u0627\u0644: \u064a\u064f\u0645\u0646\u0639 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0642\u0635\u0648\u0631 \u0643\u0628\u062f\u064a \u0645\u062a\u0648\u0633\u0637 \u0625\u0644\u0649 \u062d\u0627\u062f\u060c \u0648\u0627\u0644\u062d\u0648\u0627\u0645\u0644 \u0648\u0627\u0644\u0645\u0631\u0636\u0639\u0627\u062a.
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