\u0627\u0644\u0648\u0638\u0627\u0626\u0641 \u0648\u0627\u0644\u0645\u0624\u0634\u0631\u0627\u062a:
\n\u0623\u0642\u0631\u0627\u0635 \u0625\u064a\u0645\u0627\u062a\u064a\u0646\u064a\u0628 \u0645\u064a\u0633\u064a\u0644\u0627\u062a\/\u0643\u0628\u0633\u0648\u0644\u0627\u062a \u0625\u064a\u0645\u0627\u062a\u064a\u0646\u064a\u0628 \u0645\u064a\u0633\u064a\u0644\u0627\u062a: 1. \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0645\u0632\u0645\u0646\u0629 \u0623\u0648 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0645\u062a\u0633\u0627\u0631\u0639\u0629 \u0623\u0648 \u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0627\u0646\u0641\u062c\u0627\u0631 \u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062f\u0645 \u0627\u0644\u0646\u062e\u0627\u0639\u064a \u0627\u0644\u0645\u0632\u0645\u0646 \u0627\u0644\u0625\u064a\u062c\u0627\u0628\u064a \u0644\u0643\u0631\u0648\u0645\u0648\u0633\u0648\u0645 \u0641\u064a\u0644\u0627\u062f\u0644\u0641\u064a\u0627 (Ph+CML). 2. \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0628\u0627\u0644\u063a\u064a\u0646 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0623\u0648\u0631\u0627\u0645 \u0627\u0646\u0633\u062c\u0629 \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0647\u0636\u0645\u064a \u0627\u0644\u062e\u0628\u064a\u062b\u0629 \u063a\u064a\u0631 \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u0627\u0633\u062a\u0626\u0635\u0627\u0644 \u0648\/\u0623\u0648 \u0627\u0644\u0646\u0642\u064a\u0644\u064a\u0629 (GIST). 3. \u0628\u0627\u0644\u0627\u0634\u062a\u0631\u0627\u0643 \u0645\u0639 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a \u0644\u0639\u0644\u0627\u062c \u0645\u0631\u0636\u0649 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0627\u0644\u0630\u064a\u0646 \u062a\u0645 \u062a\u0634\u062e\u064a\u0635 \u0625\u0635\u0627\u0628\u062a\u0647\u0645 \u062d\u062f\u064a\u062b\u064b\u0627 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062f\u0645 \u0627\u0644\u0644\u064a\u0645\u0641\u0627\u0648\u064a \u0627\u0644\u062d\u0627\u062f \u0625\u064a\u062c\u0627\u0628\u064a \u0643\u0631\u0648\u0645\u0648\u0633\u0648\u0645 \u0641\u064a\u0644\u0627\u062f\u0644\u0641\u064a\u0627 (Ph+ALL). 4. \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0628\u0627\u0644\u063a\u064a\u0646 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062f\u0645 \u0627\u0644\u0644\u064a\u0645\u0641\u0627\u0648\u064a \u0627\u0644\u062d\u0627\u062f \u0627\u0644\u0645\u0646\u062a\u0643\u0633 \u0648\u0627\u0644\u0645\u0633\u062a\u0639\u0635\u064a \u0641\u064a \u0641\u064a\u0644\u0627\u062f\u0644\u0641\u064a\u0627 (Ph+ALL). 5. \u062a\u0623\u062a\u064a \u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0627\u0644\u0633\u0644\u0627\u0645\u0629 \u0648\u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0644\u0644\u0645\u0624\u0634\u0631\u0627\u062a \u0627\u0644\u062a\u0627\u0644\u064a\u0629 \u0628\u0634\u0643\u0644 \u0623\u0633\u0627\u0633\u064a \u0645\u0646 \u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0623\u0628\u062d\u0627\u062b \u0627\u0644\u0623\u062c\u0646\u0628\u064a\u0629\u060c \u0648\u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u062e\u0627\u0635\u0629 \u0628\u0627\u0644\u0633\u0643\u0627\u0646 \u0627\u0644\u0635\u064a\u0646\u064a\u064a\u0646 \u0645\u062d\u062f\u0648\u062f\u0629: (1) \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0628\u0627\u0644\u063a\u064a\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0641\u0631\u0637 \u0627\u0644\u064a\u0648\u0632\u064a\u0646\u064a\u0627\u062a (HES) \u0648\/\u0623\u0648 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062f\u0645 \u0627\u0644\u064a\u0648\u0632\u064a\u0646\u064a \u0627\u0644\u0645\u0632\u0645\u0646 (CEL) ) \u0645\u0639 \u0643\u064a\u0646\u0627\u0632 \u0627\u0644\u0627\u0646\u062f\u0645\u0627\u062c FIP1L1-PDGFR\u03b1. (2) \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0628\u0627\u0644\u063a\u064a\u0646 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u062e\u0644\u0644 \u0627\u0644\u062a\u0646\u0633\u062c \u0627\u0644\u0646\u0642\u0648\u064a\/\u0645\u0631\u0636 \u062a\u0643\u0627\u062b\u0631 \u0627\u0644\u0646\u0642\u0648\u064a (MDS\/MPD) \u0645\u0639 \u0625\u0639\u0627\u062f\u0629 \u062a\u0631\u062a\u064a\u0628 \u062c\u064a\u0646\u0627\u062a \u0645\u0633\u062a\u0642\u0628\u0644 \u0639\u0627\u0645\u0644 \u0627\u0644\u0646\u0645\u0648 \u0627\u0644\u0645\u0634\u062a\u0642 \u0645\u0646 \u0627\u0644\u0635\u0641\u0627\u0626\u062d \u0627\u0644\u062f\u0645\u0648\u064a\u0629 (PDGFR). (3) \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0628\u0627\u0644\u063a\u064a\u0646 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0643\u062b\u0631\u0629 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0628\u062f\u064a\u0646\u0629 \u0627\u0644\u062c\u0647\u0627\u0632\u064a\u0629 \u0627\u0644\u0639\u062f\u0648\u0627\u0646\u064a\u0629 (ASM) \u0628\u062f\u0648\u0646 \u0637\u0641\u0631\u0629 \u062c\u064a\u0646\u064a\u0629 D816Vc-Kit \u0623\u0648 \u0637\u0641\u0631\u0629 \u062c\u064a\u0646\u064a\u0629 \u063a\u064a\u0631 \u0645\u0639\u0631\u0648\u0641\u0629 \u0644\u0640 c-Kit. (4) \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0633\u0627\u0631\u0643\u0648\u0645\u0627 \u0627\u0644\u0644\u064a\u0641\u064a\u0629 \u0627\u0644\u062c\u0644\u062f\u064a\u0629 \u0627\u0644\u062d\u062f\u0628\u064a\u0629 \u063a\u064a\u0631 \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u0627\u0643\u062a\u0634\u0627\u0641 \u0623\u0648 \u0627\u0644\u0645\u062a\u0643\u0631\u0631\u0629 \u0623\u0648 \u0627\u0644\u0646\u0642\u064a\u0644\u064a\u0629 (DFSP). (5) \u0644\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0633\u0627\u0639\u062f \u0644\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0628\u0627\u0644\u063a\u064a\u0646 \u0627\u0644\u0630\u064a\u0646 \u0644\u062f\u064a\u0647\u0645 \u062e\u0637\u0631 \u0643\u0628\u064a\u0631 \u0644\u0644\u062a\u0643\u0631\u0627\u0631 \u0628\u0639\u062f \u0627\u0644\u0627\u0633\u062a\u0626\u0635\u0627\u0644 \u0627\u0644\u062c\u0631\u0627\u062d\u064a \u0644\u0645\u062c\u0645\u0648\u0639\u0629 (CD117)-GIST \u0627\u0644\u0625\u064a\u062c\u0627\u0628\u064a\u0629. \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0644\u062f\u064a\u0647\u0645 \u062e\u0637\u0631 \u0645\u0646\u062e\u0641\u0636 \u062c\u062f\u064b\u0627 \u0648\u0645\u0646\u062e\u0641\u0636 \u0644\u0644\u062a\u0643\u0631\u0627\u0631 \u064a\u062c\u0628 \u0623\u0644\u0627 \u064a\u062a\u0644\u0642\u0648\u0627 \u0647\u0630\u0627 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0633\u0627\u0639\u062f.<\/p>\n
\u0627\u0644\u062c\u0631\u0639\u0629 \u0648\u0627\u0644\u0625\u062f\u0627\u0631\u0629:
\n\u0623\u0642\u0631\u0627\u0635 \u0625\u064a\u0645\u0627\u062a\u064a\u0646\u064a\u0628 \u0645\u064a\u0633\u064a\u0644\u0627\u062a: 1. \u064a\u062c\u0628 \u0623\u0646 \u064a\u062a\u0645 \u0627\u0644\u0639\u0644\u0627\u062c \u0645\u0646 \u0642\u0628\u0644 \u0637\u0628\u064a\u0628 \u0630\u0648 \u062e\u0628\u0631\u0629 \u0641\u064a \u0639\u0644\u0627\u062c \u0645\u0631\u0636\u0649 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u062e\u0628\u064a\u062b\u0629. \u064a\u0646\u0628\u063a\u064a \u062a\u0646\u0627\u0648\u0644 \u0625\u064a\u0645\u0627\u062a\u064a\u0646\u064a\u0628 \u0645\u064a\u0633\u064a\u0644\u0627\u062a \u0645\u0639 \u0648\u062c\u0628\u0627\u062a \u0627\u0644\u0637\u0639\u0627\u0645 \u0648\u0643\u0648\u0628 \u0643\u0628\u064a\u0631 \u0645\u0646 \u0627\u0644\u0645\u0627\u0621 \u0644\u062a\u0642\u0644\u064a\u0644 \u0645\u062e\u0627\u0637\u0631 \u0627\u0636\u0637\u0631\u0627\u0628\u0627\u062a \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0647\u0636\u0645\u064a. \u0639\u0627\u062f\u0629\u060c \u064a\u062a\u0646\u0627\u0648\u0644 \u0627\u0644\u0628\u0627\u0644\u063a\u0648\u0646 400 \u0645\u0644\u063a \u0623\u0648 600 \u0645\u0644\u063a \u0645\u0631\u0629 \u0648\u0627\u062d\u062f\u0629 \u0641\u064a \u0627\u0644\u064a\u0648\u0645\u060c \u0648\u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u064a\u0648\u0645\u064a\u0629 \u0647\u064a 800 \u0645\u0644\u063a\u060c \u0623\u064a 400 \u0645\u0644\u063a \u0645\u0631\u062a\u064a\u0646 \u0641\u064a \u0627\u0644\u064a\u0648\u0645 (\u0641\u064a \u0627\u0644\u0635\u0628\u0627\u062d \u0648\u0627\u0644\u0645\u0633\u0627\u0621). \u064a\u062a\u0646\u0627\u0648\u0644\u0647 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0648\u0627\u0644\u0645\u0631\u0627\u0647\u0642\u0648\u0646 \u0645\u0631\u0629 \u0623\u0648 \u0645\u0631\u062a\u064a\u0646 \u064a\u0648\u0645\u064a\u064b\u0627 (\u0641\u064a \u0627\u0644\u0635\u0628\u0627\u062d \u0648\u0627\u0644\u0645\u0633\u0627\u0621). \u064a\u0645\u0643\u0646 \u0644\u0644\u0645\u0631\u0636\u0649 (\u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0627\u0644\u0623\u0637\u0641\u0627\u0644) \u0627\u0644\u0630\u064a\u0646 \u0644\u0627 \u064a\u0633\u062a\u0637\u064a\u0639\u0648\u0646 \u0628\u0644\u0639 \u0627\u0644\u0623\u0642\u0631\u0627\u0635 \u062a\u0641\u0631\u064a\u0642 \u0627\u0644\u0623\u0642\u0631\u0627\u0635 \u0641\u064a \u0627\u0644\u0645\u0627\u0621 \u0623\u0648 \u0639\u0635\u064a\u0631 \u0627\u0644\u062a\u0641\u0627\u062d \u0628\u062f\u0648\u0646 \u063a\u0627\u0632 (\u062d\u0648\u0627\u0644\u064a 50 \u0645\u0644 \u0644\u0623\u0642\u0631\u0627\u0635 100 \u0645\u0644\u063a \u0648\u062d\u0648\u0627\u0644\u064a 200 \u0645\u0644 \u0644\u0623\u0642\u0631\u0627\u0635 400 \u0645\u0644\u063a). \u064a\u062c\u0628 \u062a\u062d\u0631\u064a\u0643 \u0627\u0644\u0645\u0639\u0644\u0642 \u0648\u062a\u0646\u0627\u0648\u0644\u0647 \u0641\u0648\u0631\u064b\u0627 \u0628\u0645\u062c\u0631\u062f \u062a\u0641\u0643\u0643 \u0627\u0644\u0642\u0631\u0635 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